2. Gene
  3. ATP6V0B - ATPase H+ transporting V0 subunit b Gene

ATP6V0B - ATPase H+ transporting V0 subunit b Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ATP6F; HATPL; VMA16

Gene ID: 533 | Gene type: protein coding

About ATP6V0B

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,974,960-43,978,295 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 52.4), kidney (RPKM 31.0) and 25 other tissues.

Summary

This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this Enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ATP6V0B Products(3)

mRNA Protein Name
NM_001039457.3 NP_001034546.1 V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 2
NM_001294333.2 NP_001281262.1 V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 3
NM_004047.5 NP_004038.1 V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
33065002 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP6V0B Protein Structure

ATP-synt_C

ATP-synt_C: ATP synthase subunit C (49 - 112)

ATP-synt_C

ATP-synt_C: ATP synthase subunit C (136 - 196)

  • 0
  • 100
  • 205 a.a.
Protein Preferred Names Protein Names

V-type proton ATPase 21 kDa proteolipid subunit c''

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01219 ATP6V0B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP6V0B MGD MGI:1890510
Felis catus ATP6V0B VGNC VGNC:68695
Rattus norvegicus ATP6V0B RGD RGD:1308303
Bos taurus ATP6V0B VGNC VGNC:26310
Canis familiaris ATP6V0B VGNC VGNC:38271
Macaca mulatta ATP6V0B VGNC VGNC:70187