ATP6V0B - ATPase H+ transporting V0 subunit b Gene

Homo sapiens

Also known as ATP6F; HATPL; VMA16

Gene ID: 533 | Gene type: protein coding

About ATP6V0B

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,974,960-43,978,295 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 52.4), kidney (RPKM 31.0) and 25 other tissues.

Summary

This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit Enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this Enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ATP6V0B Products(3)

mRNA	Protein	Name
NM_001039457.3	NP_001034546.1	V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 2
NM_001294333.2	NP_001281262.1	V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 3
NM_004047.5	NP_004038.1	V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	33065002	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP6V0B Protein Structure

ATP-synt_C

0
100
205 a.a.

Protein Preferred Names

Protein Names

V-type proton ATPase 21 kDa proteolipid subunit c''

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

ATP6V0B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP6V0B	Q99437	TMEM242	Homo sapiens	Q9NWH2	Y2H Array	32296183
Intra	ATP6V0B	Q99437	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	ATP6V0B	Q99437	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	ATP6V0B	Q99437	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	ATP6V0B	Q99437	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	ATP6V0B	Q99437	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	ATP6V0B	Q99437	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	GPR61	Homo sapiens	Q9BZJ8	Y2H Array	32296183
Intra	ATP6V0B	Q99437	GPR61	Homo sapiens	Q9BZJ8	Validated Y2H	32296183
Intra	ATP6V0B	Q99437	GPR61	Homo sapiens	Q9BZJ8	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	ATP6V0B	Q99437	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	ATP6V0B	Q99437	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	ATP6V0B	Q99437	ADGRG3	Homo sapiens	Q86Y34	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	ADGRG3	Homo sapiens	Q86Y34	Y2H Array	32296183
Intra	ATP6V0B	Q99437	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	ATP6V0B	Q99437	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	ATP6V0B	Q99437	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	ATP6V0B	Q99437	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	ATP6V0B	Q99437	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	ATP6V0B	Q99437	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	ATP6V0B	Q99437	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	ATP6V0B	Q99437	KLRC1	Homo sapiens	P26715	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01219	ATP6V0B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATP6V0B	MGD	MGI:1890510
Felis catus	ATP6V0B	VGNC	VGNC:68695
Rattus norvegicus	ATP6V0B	RGD	RGD:1308303
Bos taurus	ATP6V0B	VGNC	VGNC:26310
Canis familiaris	ATP6V0B	VGNC	VGNC:38271
Macaca mulatta	ATP6V0B	VGNC	VGNC:70187

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