FAM83B - family with sequence similarity 83 member B Gene

Homo sapiens

Also known as C6orf143

Gene ID: 222584 | Gene type: protein coding

About FAM83B

This gene has 1 transcript (splice variant), 254 orthologues and 7 paralogues. Biased expression in skin (RPKM 10.9), esophagus (RPKM 6.8) and 12 other tissues.

Summary

Enables epidermal growth factor receptor binding activity; phosphatidylinositol 3-kinase binding activity; and protein kinase binding activity. Involved in cell population proliferation and epidermal growth factor receptor signaling pathway. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Apr 2022]

FAM83B Products(1)

mRNA	Protein	Name
NM_001010872.3	NP_001010872.1	protein FAM83B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	23912460	GOA
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI IPI: Inferred from physical interaction	23676467	GOA
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	23676467	GOA
NOT enables phospholipase D activity	IDA IDA: Inferred from direct assay	22886302	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23455922	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	23676467	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22886302	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	23912460	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	23676467	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22886302	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22886302	GOA
located in membrane	IDA IDA: Inferred from direct assay	22886302	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FAM83B Protein Structure

DUF1669

0
200
400
600
800
1011 a.a.

Protein Preferred Names

Protein Names

protein FAM83B

FAM83B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FAM83B	Q5T0W9	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	29789297
Intra	FAM83B	Q5T0W9	CSNK1A1	Homo sapiens	P48729	IF	29789297
Intra	FAM83B	Q5T0W9	CSNK1A1	Homo sapiens	P48729	Protein Kinase Assay	29789297

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04722	FAM83B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FAM83B	MGD	MGI:2685362
Macaca mulatta	FAM83B	VGNC	VGNC:72313
Felis catus	FAM83B	VGNC	VGNC:62128
Canis familiaris	FAM83B	VGNC	VGNC:40700
Bos taurus	FAM83B	VGNC	VGNC:28833
Rattus norvegicus	FAM83B	RGD	RGD:1311988

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