CSNK1A1 - casein kinase 1 alpha 1 Gene

Homo sapiens

Also known as CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p

Gene ID: 1452 | Gene type: protein coding

About CSNK1A1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,492,982-149,551,439 (from NCBI)

This gene has 17 transcripts (splice variants), 234 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 69.2), gall bladder (RPKM 47.2) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]

CSNK1A1 Products(4)

mRNA	Protein	Name
NM_001025105.3	NP_001020276.1	casein kinase I isoform alpha isoform 1
NM_001271741.2	NP_001258670.1	casein kinase I isoform alpha isoform 3
NM_001271742.2	NP_001258671.1	casein kinase I isoform alpha isoform 4
NM_001892.6	NP_001883.4	casein kinase I isoform alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16511560	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	32645325	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18305108	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	11955436	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	25500533	GOA
involved in cellular response to nutrient	IDA IDA: Inferred from direct assay	22017875	GOA
involved in intermediate filament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23902688	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21331045	GOA
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	11955436	GOA
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	25500533	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	22017875	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19364825	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	11955436	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18305108	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	11955436	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
colocalizes with keratin filament	IDA IDA: Inferred from direct assay	23902688	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	18305108	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	18305108	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSNK1A1 Protein Structure

Pkinase

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

casein kinase I isoform alpha

CKI-alpha

Recombinant CSNK1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72872	Casein Kinase I alpha Protein, Human (sf9, GST)	P48729-1 (M1-F337)	≥95%

Related Diseases

Diseases

Alias

Enterobiasis

Oxyuriasis	Pinworm Infection
Enterobius Vermicularis Infection	Threadworm Infection
Oxyuris Vermicularis Infection	Enterobiosis
Pinworm	Pinworm Disease
Seatworm Infection	Enterobiasis Threadworm
Pinworm Infestation	Seatworm

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Desmoid Tumor

Aggressive Fibromatosis	Desmoid Type Fibromatosis
Familial Infiltrative Fibromatosis	Desmoid Disorder, Hereditary
Fif	Fibromatosis, Familial Infiltrative
Deep Fibromatosis	Desmoid Fibromatosis
Hereditary Desmoid Disease	Musculoaponeurotic Fibromatosis
Desmoid-Type Fibromatosis	Fibromatosis, Aggressive
Desmoid Disease, Hereditary	Musculo-Aponeurotic Fibromatosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145939	BAY-888	Inhibitor	98.35%	Unkown
HY-148491	CSNK1-IN-2	Inhibitor	98.20%	Unkown
HY-148489	CSNK1-IN-1	Inhibitor	99.23%	Unkown
HY-RS03245	CSNK1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03248	CSNK1G1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CSNK1A1	VGNC	VGNC:84290
Bos taurus	CSNK1A1	VGNC	VGNC:55205
Mus musculus	CSNK1A1	MGD	MGI:1934950
Felis catus	CSNK1A1	VGNC	VGNC:102183
Rattus norvegicus	CSNK1A1	RGD	RGD:71098
Others	CSNK1A1	NCBI

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