IKZF2 - IKAROS family zinc finger 2 Gene

Homo sapiens

Also known as ANF1A2; HELIOS; ZNF1A2; ZNFN1A2

Gene ID: 22807 | Gene type: protein coding

About IKZF2

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:212,999,698-213,152,456 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 11 paralogues. Broad expression in esophagus (RPKM 4.7), urinary bladder (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with Other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

IKZF2 Products(7)

mRNA	Protein	Name
NM_001079526.2	NP_001072994.1	zinc finger protein Helios isoform 2
NM_001371274.1	NP_001358203.1	zinc finger protein Helios isoform 1
NM_001371275.1	NP_001358204.1	zinc finger protein Helios isoform 2
NM_001371276.1	NP_001358205.1	zinc finger protein Helios isoform 2
NM_001371277.1	NP_001358206.1	zinc finger protein Helios isoform 3
NM_001387220.1	NP_001374149.1	zinc finger protein Helios isoform 1
NM_016260.3	NP_057344.2	zinc finger protein Helios isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23088713	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKZF2 Protein Structure

zf-H2C2_2

0
100
200
300
400
526 a.a.

Protein Preferred Names

Protein Names

zinc finger protein Helios

ikaros family zinc finger protein 2

IKZF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IKZF2	Q9UKS7	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	25416956
Intra	IKZF2	Q9UKS7	CTBP2	Homo sapiens	P56545-3	Y2H Array	25416956
Intra	IKZF2	Q9UKS7	LONRF1	Homo sapiens	Q17RB8	Y2H Prey Pooling	25416956
Intra	IKZF2	Q9UKS7	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	25416956
Cross	IKZF2	Q9UKS7	Hoxa1	Mus musculus	P09022	Y2H	23088713
Cross	IKZF2	Q9UKS7	Hoxa1	Mus musculus	P09022	Pull Down	23088713
Intra	IKZF2	Q9UKS7	CTBP2	Homo sapiens	P56545	Y2H Array	25416956
Intra	IKZF2	Q9UKS7	AQP1	Homo sapiens	P29972	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145776	ALV1	Inhibitor	96.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144998	NVP-DKY709	Degrader	98.86%	Unkown
HY-157334	DEG-77	Degrader	98.31%	Unkown
HY-159647	PLX-4545		/	Unkown
HY-RS06666	IKZF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168614	MGD-4	Degrader	/	Unkown
HY-168615	MGD-28	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IKZF2	RGD	RGD:1308686
Felis catus	IKZF2	VGNC	VGNC:80245
Canis familiaris	IKZF2	VGNC	VGNC:41924
Macaca mulatta	IKZF2	VGNC	VGNC:73586
Bos taurus	IKZF2	VGNC	VGNC:56125
Mus musculus	IKZF2	MGD	MGI:1342541

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