CPEB3 - cytoplasmic polyadenylation element binding protein 3 Gene

Homo sapiens

Gene ID: 22849 | Gene type: protein coding

About CPEB3

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:92,046,692-92,291,233 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 68 phenotypes. Broad expression in brain (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues.

Summary

Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CPEB3 Products(2)

mRNA	Protein	Name
NM_001178137.2	NP_001171608.1	cytoplasmic polyadenylation element-binding protein 3 isoform 2
NM_014912.5	NP_055727.3	cytoplasmic polyadenylation element-binding protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	22730302	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22711986	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20639532	GOA
enables translation factor activity, RNA binding	IDA IDA: Inferred from direct assay	22711986	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	21336257	GOA
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20639532	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20639532	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	22711986	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	21336257	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	21336257	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	21336257	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20639532	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	22730302	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20639532	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPEB3 Protein Structure

RRM_1

0
200
400
600
698 a.a.

Protein Preferred Names

Protein Names

cytoplasmic polyadenylation element-binding protein 3

CPE-BP3

CPEB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CPEB3	Q8NE35	TOB1	Homo sapiens	P50616	Anti Tag CoIP	21336257
Intra	CPEB3	Q8NE35	TOB1	Homo sapiens	P50616	Pull Down	21336257
Intra	CPEB3	Q8NE35	TOB1	Homo sapiens	P50616	Anti Bait CoIP	21336257

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03093	CPEB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CPEB3	VGNC	VGNC:71449
Mus musculus	CPEB3	MGD	MGI:2443075
Canis familiaris	CPEB3	VGNC	VGNC:39553
Bos taurus	CPEB3	VGNC	VGNC:27649
Rattus norvegicus	CPEB3	RGD	RGD:1564670
Others	CPEB3	NCBI

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