2. Gene
  3. CPEB3 - cytoplasmic polyadenylation element binding protein 3 Gene

CPEB3 - cytoplasmic polyadenylation element binding protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 22849 | Gene type: protein coding

About CPEB3

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:92,046,692-92,291,233 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 68 phenotypes. Broad expression in brain (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues.

Summary

Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CPEB3 Products(2)

mRNA Protein Name
NM_001178137.2 NP_001171608.1 cytoplasmic polyadenylation element-binding protein 3 isoform 2
NM_014912.5 NP_055727.3 cytoplasmic polyadenylation element-binding protein 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
22730302 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
22711986 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20639532 GOA
enables translation factor activity, RNA binding IDA
IDA: Inferred from direct assay
22711986 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: Inferred from direct assay
21336257 GOA
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20639532 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20639532 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
22711986 GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
21336257 GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
IDA: Inferred from direct assay
21336257 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
21336257 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20639532 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
22730302 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20639532 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPEB3 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (443 - 504)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

cytoplasmic polyadenylation element-binding protein 3

CPE-BP3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03093 CPEB3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CPEB3 VGNC VGNC:71449
Mus musculus CPEB3 MGD MGI:2443075
Canis familiaris CPEB3 VGNC VGNC:39553
Bos taurus CPEB3 VGNC VGNC:27649
Rattus norvegicus CPEB3 RGD RGD:1564670
Others CPEB3 NCBI