SEPHS1 - selenophosphate synthetase 1 Gene

Homo sapiens

Also known as SPS; SELD; SPS1

Gene ID: 22929 | Gene type: protein coding

About SEPHS1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:13,317,428-13,348,293 (from NCBI)

This gene has 6 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 16.5), kidney (RPKM 11.8) and 25 other tissues.

Summary

This gene encodes an Enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]

SEPHS1 Products(4)

mRNA	Protein	Name
NM_001195602.2	NP_001182531.1	selenide, water dikinase 1 isoform 2
NM_001195604.2	NP_001182533.1	selenide, water dikinase 1 isoform 3
NM_001375769.1	NP_001362698.1	selenide, water dikinase 1 isoform 4
NM_012247.5	NP_036379.2	selenide, water dikinase 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20471958	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	20471958	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20471958	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20471958	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	20471958	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20471958	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEPHS1 Protein Structure

AIRS

AIRS_C

0
100
200
300
392 a.a.

Protein Preferred Names

Protein Names

selenide, water dikinase 1

selenium donor protein 1

SEPHS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SEPHS1	P49903	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	ZNF526	Homo sapiens	Q8TF50	Validated Y2H	32296183
Intra	SEPHS1	P49903	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	SEPHS1	P49903	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	SEPHS1	P49903	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	ZNF474	Homo sapiens	Q6S9Z5	Validated Y2H	32296183
Intra	SEPHS1	P49903	QRICH1	Homo sapiens	Q2TAL8	Anti Tag CoIP	33961781
Intra	SEPHS1	P49903	QRICH1	Homo sapiens	Q2TAL8	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	SEPHS1	P49903	QRICH1	Homo sapiens	Q2TAL8	Y2H Array	32296183
Intra	SEPHS1	P49903	XAF1	Homo sapiens	Q6GPH4	Validated Y2H	32296183
Intra	SEPHS1	P49903	XAF1	Homo sapiens	Q6GPH4	Y2H Array	32296183
Intra	SEPHS1	P49903	XAF1	Homo sapiens	Q6GPH4	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	SEPHS1	P49903	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	SEPHS1	P49903	SEPHS2	Homo sapiens	Q99611	Anti Tag CoIP	33961781
Intra	SEPHS1	P49903	SEPHS1	Homo sapiens	P49903	Y2H Pooling	16189514
Intra	SEPHS1	P49903	ZBTB25	Homo sapiens	P24278	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	ZBTB25	Homo sapiens	P24278	Y2H Array	32296183
Intra	SEPHS1	P49903	SEPHS1	Homo sapiens	P49903	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	SEPHS1	Homo sapiens	P49903	Validated Y2H	32296183
Intra	SEPHS1	P49903	SEPHS1	Homo sapiens	P49903	Y2H Array	25416956
Intra	SEPHS1	P49903	SEPHS1	Homo sapiens	P49903	Y2H	21516116
Intra	SEPHS1	P49903	SEPHS1	Homo sapiens	P49903	Y2H Array	32296183
Intra	SEPHS1	P49903	ZNF276	Homo sapiens	Q8N554	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	ZNF276	Homo sapiens	Q8N554	Validated Y2H	32296183
Intra	SEPHS1	P49903	ZNF276	Homo sapiens	Q8N554	Y2H Array	32296183
Intra	SEPHS1	P49903	ZNF202	Homo sapiens	O95125	Y2H Prey Pooling	32296183
Intra	SEPHS1	P49903	ZNF202	Homo sapiens	O95125	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SEPHS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71291	SEPHS1 Protein, Human (HEK293, His)	P49903 (M1-S392)	≥95%

Related Diseases

Diseases

Alias

Myopathy, Myosin Storage, Autosomal Dominant

MSMA	Myopathy, Hyaline Body, Autosomal Dominant
Myopathy With Lysis Of Type I Myofibrils	Autosomal Dominant Hyaline Body Myopathy
Hyaline Body Myopathy Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12678	SEPHS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SEPHS1	VGNC	VGNC:46009
Felis catus	SEPHS1	VGNC	VGNC:65007
Macaca mulatta	SEPHS1	VGNC	VGNC:103863
Rattus norvegicus	SEPHS1	RGD	RGD:1311182
Mus musculus	SEPHS1	MGD	MGI:1923580
Bos taurus	SEPHS1	VGNC	VGNC:34448
Others	SEPHS1	NCBI

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