ELL2 - elongation factor for RNA polymerase II 2 Gene

Homo sapiens

Also known as MRCCAT1

Gene ID: 22936 | Gene type: protein coding

About ELL2

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,885,098-95,961,851 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 18.5), salivary gland (RPKM 14.3) and 25 other tissues.

Summary

Involved in snRNA transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ELL2 Products(1)

mRNA	Protein	Name
NM_012081.6	NP_036213.2	RNA polymerase II elongation factor ELL2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21729782	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in snRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22195968	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription elongation factor complex	IDA IDA: Inferred from direct assay	22195968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELL2 Protein Structure

ELL

Occludin_ELL

0
100
200
300
400
500
600
640 a.a.

Protein Preferred Names

Protein Names

RNA polymerase II elongation factor ELL2

ELL-related RNA polymerase II, elongation factor

Related Diseases

Diseases

Alias

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04309	ELL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ELL2	VGNC	VGNC:97416
Canis familiaris	ELL2	VGNC	VGNC:40307
Bos taurus	ELL2	VGNC	VGNC:28436
Macaca mulatta	ELL2	VGNC	VGNC:84368
Mus musculus	ELL2	MGD	MGI:2183438
Rattus norvegicus	ELL2	RGD	RGD:1309296
Others	ELL2	NCBI

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