EAF1 - ELL associated factor 1 Gene

Homo sapiens

Gene ID: 85403 | Gene type: protein coding

About EAF1

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:15,427,598-15,442,613 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 21.6), brain (RPKM 8.9) and 25 other tissues.

Summary

Enables transcription elongation regulator activity. Involved in regulation of transcription elongation from RNA polymerase II promoter. Located in intercellular bridge and nuclear body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

EAF1 Products(1)

mRNA	Protein	Name
NM_033083.7	NP_149074.3	ELL-associated factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables transcription elongation factor activity	IMP IMP: Inferred from mutant phenotype	32087315	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	32087315	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription elongation factor complex	IDA IDA: Inferred from direct assay	22195968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EAF1 Protein Structure

EAF

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

ELL-associated factor 1

ELL (eleven nineteen lysine-rich leukemia gene)-associated factor 1

EAF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EAF1	Q96JC9	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	25416956
Intra	EAF1	Q96JC9	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	25416956
Intra	EAF1	Q96JC9	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	25416956
Intra	EAF1	Q96JC9	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	25416956
Intra	EAF1	Q96JC9	MAB21L3	Homo sapiens	Q8N8X9	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	MAB21L3	Homo sapiens	Q8N8X9	Y2H Array	32296183
Intra	EAF1	Q96JC9	TNFAIP8	Homo sapiens	O95379	Y2H Array	32296183
Intra	EAF1	Q96JC9	TNFAIP8	Homo sapiens	O95379	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	EAF1	Q96JC9	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	EAF1	Q96JC9	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ARID4B	Homo sapiens	Q4LE39-3	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ARID4B	Homo sapiens	Q4LE39-3	Y2H Array	32296183
Intra	EAF1	Q96JC9	YAF2	Homo sapiens	Q8IY57-5	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	YAF2	Homo sapiens	Q8IY57-5	Y2H Array	32296183
Intra	EAF1	Q96JC9	VAX1	Homo sapiens	Q5SQQ9-2	Y2H Array	32296183
Intra	EAF1	Q96JC9	VAX1	Homo sapiens	Q5SQQ9-2	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	CCDC150	Homo sapiens	Q8NCX0-3	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	CCDC150	Homo sapiens	Q8NCX0-3	Y2H Array	32296183
Intra	EAF1	Q96JC9	SEMG1	Homo sapiens	P04279-2	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	SEMG1	Homo sapiens	P04279-2	Y2H Array	32296183
Intra	EAF1	Q96JC9	GRHL3	Homo sapiens	Q8TE85-2	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GRHL3	Homo sapiens	Q8TE85-2	Y2H Array	32296183
Intra	EAF1	Q96JC9	FAM228A	Homo sapiens	Q86W67	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	FAM228A	Homo sapiens	Q86W67	Y2H Array	32296183
Intra	EAF1	Q96JC9	GCSAML	Homo sapiens	Q5JQS6	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GCSAML	Homo sapiens	Q5JQS6	Y2H Array	32296183
Intra	EAF1	Q96JC9	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	EAF1	Q96JC9	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	25416956
Intra	EAF1	Q96JC9	DNTTIP1	Homo sapiens	Q9H147	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	DNTTIP1	Homo sapiens	Q9H147	Validated Y2H	32296183
Intra	EAF1	Q96JC9	DNTTIP1	Homo sapiens	Q9H147	Y2H Array	32296183
Intra	EAF1	Q96JC9	ZNF143	Homo sapiens	P52747	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ZNF143	Homo sapiens	P52747	Y2H Array	32296183
Intra	EAF1	Q96JC9	AP2M1	Homo sapiens	Q96CW1	Y2H Array	32296183
Intra	EAF1	Q96JC9	AP2M1	Homo sapiens	Q96CW1	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	EAF1	Q96JC9	SRP14	Homo sapiens	P37108	Y2H Array	32296183
Intra	EAF1	Q96JC9	SRP14	Homo sapiens	P37108	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	PSME3	Homo sapiens	P61289	Y2H Array	25416956
Intra	EAF1	Q96JC9	PSME3	Homo sapiens	P61289	BFG-2H	27107012
Intra	EAF1	Q96JC9	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	EAF1	Q96JC9	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	EAF1	Q96JC9	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	PIH1D1	Homo sapiens	Q9NWS0	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	PIH1D1	Homo sapiens	Q9NWS0	Validated Y2H	32296183
Intra	EAF1	Q96JC9	PIH1D1	Homo sapiens	Q9NWS0	Y2H Array	32296183
Intra	EAF1	Q96JC9	GADD45GIP1	Homo sapiens	Q8TAE8	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GADD45GIP1	Homo sapiens	Q8TAE8	Y2H Array	32296183
Intra	EAF1	Q96JC9	ELL2	Homo sapiens	O00472	Anti Tag CoIP	33961781
Intra	EAF1	Q96JC9	ELL2	Homo sapiens	O00472	Anti Tag CoIP	28514442
Intra	EAF1	Q96JC9	ELL2	Homo sapiens	O00472	Y2H Array	32296183
Intra	EAF1	Q96JC9	ELL2	Homo sapiens	O00472	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ELL2	Homo sapiens	O00472	Anti Tag CoIP	21729782
Intra	EAF1	Q96JC9	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	EAF1	Q96JC9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	EAF1	Q96JC9	GTF2H4	Homo sapiens	Q92759	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	GTF2H4	Homo sapiens	Q92759	Y2H Array	32296183
Intra	EAF1	Q96JC9	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	EAF1	Q96JC9	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	EAF1	Q96JC9	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	EAF1	Q96JC9	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	EAF1	Q96JC9	ELL3	Homo sapiens	Q9HB65	Anti Tag CoIP	21729782
Intra	EAF1	Q96JC9	ELL3	Homo sapiens	Q9HB65	Anti Tag CoIP	33961781
Intra	EAF1	Q96JC9	ELL3	Homo sapiens	Q9HB65	Anti Tag CoIP	28514442
Intra	EAF1	Q96JC9	ELL3	Homo sapiens	Q9HB65	Validated Y2H	32296183
Intra	EAF1	Q96JC9	GTF2H1	Homo sapiens	P32780	Y2H Array	32296183
Intra	EAF1	Q96JC9	GTF2H1	Homo sapiens	P32780	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	EAF1	Q96JC9	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	EAF1	Q96JC9	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	EAF1	Q96JC9	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	EAF1	Q96JC9	STAC3	Homo sapiens	Q96MF2	Validated Y2H	32296183
Intra	EAF1	Q96JC9	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	STAC3	Homo sapiens	Q96MF2	Y2H Array	32296183
Intra	EAF1	Q96JC9	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	TNNI1	Homo sapiens	P19237	Y2H Array	32296183
Intra	EAF1	Q96JC9	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	EAF1	Q96JC9	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	25416956
Intra	EAF1	Q96JC9	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	EAF1	Q96JC9	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	EAF1	Q96JC9	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	EAF1	Q96JC9	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ZNF202	Homo sapiens	O95125	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	ZNF202	Homo sapiens	O95125	Y2H Array	32296183
Intra	EAF1	Q96JC9	RYBP	Homo sapiens	Q8N488	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	RYBP	Homo sapiens	Q8N488	Y2H Array	32296183
Intra	EAF1	Q96JC9	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	EAF1	Q96JC9	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	EAF1	Q96JC9	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Eaf

Eosinophilic Angiocentric Fibrosis	Sinonasal Eosinophilic Angiocentric Fibrosis
Igg4-Related Eosinophilic Angiocentric Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04119	EAF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EAF1	VGNC	VGNC:61700
Bos taurus	EAF1	VGNC	VGNC:28294
Canis familiaris	EAF1	VGNC	VGNC:40171
Macaca mulatta	EAF1	VGNC	VGNC:71874
Rattus norvegicus	EAF1	RGD	RGD:1310057
Mus musculus	EAF1	MGD	MGI:1921677
Others	EAF1	NCBI

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