ACIN1 - apoptotic chromatin condensation inducer 1 Gene

Homo sapiens

Also known as ACN; ACINUS; fSAP152

Gene ID: 22985 | Gene type: protein coding

About ACIN1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,058,564-23,095,614 (from NCBI)

This gene has 23 transcripts (splice variants) and 263 orthologues. Ubiquitous expression in bone marrow (RPKM 24.7), spleen (RPKM 23.3) and 25 other tissues.

Summary

Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by Caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

ACIN1 Products(6)

mRNA	Protein	Name
NM_001164814.1	NP_001158286.1	apoptotic chromatin condensation inducer in the nucleus isoform 2
NM_001164815.1	NP_001158287.1	apoptotic chromatin condensation inducer in the nucleus isoform 3
NM_001164816.2	NP_001158288.1	apoptotic chromatin condensation inducer in the nucleus isoform 4
NM_001164817.2	NP_001158289.1	apoptotic chromatin condensation inducer in the nucleus isoform 5
NM_001386863.1	NP_001373792.1	apoptotic chromatin condensation inducer in the nucleus isoform 6
NM_014977.3	NP_055792.1	apoptotic chromatin condensation inducer in the nucleus isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic chromosome condensation	IDA IDA: Inferred from direct assay	10490026	GOA
involved in erythrocyte differentiation	IEP IEP: Inferred from expression pattern	11208865	GOA
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	12665594	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12665594	GOA
involved in positive regulation of monocyte differentiation	IEP IEP: Inferred from expression pattern	12393560	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ASAP complex	IDA IDA: Inferred from direct assay	12665594	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	16314458	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	20966198	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10490026	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACIN1 Protein Structure

SAP

RRM_5

0
300
600
900
1200
1341 a.a.

Protein Preferred Names

Protein Names

apoptotic chromatin condensation inducer in the nucleus

functional spliceosome-associated protein 152

Related Diseases

Diseases

Alias

Large Cell Acanthoma

Pilar Sheath Acanthoma

Acanthoma, Pilar Sheath

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00159	ACIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACIN1	VGNC	VGNC:37507
Macaca mulatta	ACIN1	VGNC	VGNC:69437
Rattus norvegicus	ACIN1	RGD	RGD:1311945
Mus musculus	ACIN1	MGD	MGI:1891824
Bos taurus	ACIN1	VGNC	VGNC:25539
Felis catus	ACIN1	VGNC	VGNC:59509

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