SAMD4A - sterile alpha motif domain containing 4A Gene

Homo sapiens

Also known as SMG; SMGA; SAMD4; SMAUG; SMAUG1

Gene ID: 23034 | Gene type: protein coding

About SAMD4A

Cytogenetic location: 14q22.2 Genomic coordinates (GRCh38): 14:54,565,316-54,793,315 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 1 paralogue. Broad expression in testis (RPKM 19.6), heart (RPKM 19.4) and 22 other tissues.

Summary

Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008]

SAMD4A Products(3)

mRNA	Protein	Name
NM_001161576.2	NP_001155048.2	protein Smaug homolog 1 isoform 2
NM_001161577.2	NP_001155049.1	protein Smaug homolog 1 isoform 3
NM_015589.6	NP_056404.4	protein Smaug homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15778465	GOA
enables translation repressor activity	IDA IDA: Inferred from direct assay	16221671	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive regulation of translation	IDA IDA: Inferred from direct assay	16221671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAMD4A Protein Structure

SAM_1

0
200
400
600
718 a.a.

Protein Preferred Names

Protein Names

protein Smaug homolog 1

SAM domain-containing protein 4A

SAMD4A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SAMD4A	Q9UPU9	NUTM1	Homo sapiens	Q86Y26	Y2H Array	25416956
Intra	SAMD4A	Q9UPU9	NUTM1	Homo sapiens	Q86Y26	Validated Y2H	25416956
Intra	SAMD4A	Q9UPU9	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	SAMD4A	Q9UPU9	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	SAMD4A	Q9UPU9	YWHAG	Homo sapiens	P61981	SLC	36931259
Intra	SAMD4A	Q9UPU9	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	SAMD4A	Q9UPU9	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	SAMD4A	Q9UPU9	SFN	Homo sapiens	P31947	TAP	15778465
Intra	SAMD4A	Q9UPU9	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12426	SAMD4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SAMD4A	VGNC	VGNC:80853
Macaca mulatta	SAMD4A	VGNC	VGNC:77085
Mus musculus	SAMD4A	MGD	MGI:1921730
Rattus norvegicus	SAMD4A	RGD	RGD:1310361
Canis familiaris	SAMD4A	VGNC	VGNC:45852
Bos taurus	SAMD4A	VGNC	VGNC:34272

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