PEG10 - paternally expressed 10 Gene

Homo sapiens

Also known as EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1

Gene ID: 23089 | Gene type: protein coding

About PEG10

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:94,656,325-94,669,695 (from NCBI)

This gene has 9 transcripts (splice variants), 274 orthologues and 10 paralogues. Biased expression in placenta (RPKM 304.5), adrenal (RPKM 114.1) and 3 other tissues.

Summary

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic Protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and Apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

PEG10 Products(6)

mRNA	Protein	Name
NM_001040152.2	NP_001035242.1	retrotransposon-derived protein PEG10 isoform 2
NM_001172437.2	NP_001165908.1	retrotransposon-derived protein PEG10 isoform 3
NM_001172438.3	NP_001165909.1	retrotransposon-derived protein PEG10 isoform 4
NM_001184961.1	NP_001171890.1	retrotransposon-derived protein PEG10 isoform 5
NM_001184962.2	NP_001171891.1	retrotransposon-derived protein PEG10 isoform 6
NM_015068.3	NP_055883.2	retrotransposon-derived protein PEG10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15611116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	15611116	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15611116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PEG10 Protein Structure

Retrotrans_gag

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

retrotransposon-derived protein PEG10

MEF3 like 1

PEG10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PEG10	Q86TG7	RTL8C	Homo sapiens	A6ZKI3	Anti Tag CoIP	33961781
Intra	PEG10	Q86TG7	RTL8C	Homo sapiens	A6ZKI3	Validated Y2H	25416956
Intra	PEG10	Q86TG7	RTL8B	Homo sapiens	Q17RB0	Anti Tag CoIP	33961781
Intra	PEG10	Q86TG7	RTL8B	Homo sapiens	Q17RB0	Y2H Prey Pooling	25416956
Intra	PEG10	Q86TG7	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	PEG10	Q86TG7	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	PEG10	Q86TG7	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	PEG10	Q86TG7	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	PEG10	Q86TG7	LDOC1	Homo sapiens	O95751	Anti Tag CoIP	33961781
Intra	PEG10	Q86TG7	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	PEG10	Q86TG7	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma	B-All
Precursor B Lymphoblastic Lymphoma/Leukemia	C-All
Lymphoblastic Lymphoma, Nos	Common Precursor B All
Lymphoblastic B-Cell Lymphoma	Pro-B All
B-Precursor Lymphoma	Lbl - [Lymphoblastic Lymphoma]

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder

Silver-Russell Syndrome 1

Silver-Russell Syndrome	Russell-Silver Syndrome
Silver-Russell Dwarfism	Rss
SRS1	Srs
Silver Russell Dwarfism	Russell Silver Syndrome
Silver Russell Syndrome

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Spastic Paraplegia 17, Autosomal Dominant

Silver Syndrome	SPG17
Silver Spastic Paraplegia Syndrome	Spastic Paraplegia With Amyotrophy Of Hands And Feet
Hereditary Spastic Paraplegia 17	Autosomal Dominant Spastic Paraplegia Type 17
Spastic Paraplegia 17	Spastic Paraplegia-Amyotrophy Of Hands And Feet
Autosomal Dominant Spastic Paraplegia 17	Dhmn5b
Distal Hereditary Motor Neuropathy Type 5b	Paraplegia, Spastic, Autosomal Dominant, Type 17
Russell-Silver Syndrome	Neuronopathy, Distal Hereditary Motor, Type Vb

Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal	Tndm
Chromosome 6-Associated Transient Diabetes Mellitus	Dmtn
Diabetes Mellitus, 6q24-Related Transient Neonatal	Tndm1
Neonatal Diabetes Mellitus, Transient	Tndm -[Transient Neonatal Diabetes Mellitus]

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type Iii	Oi Type 3
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (66)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-140217	Azido-PEG10-amine		≥97.0%	Unkown
HY-W040270	Amino-PEG10-amine		≥97.0%	Unkown
HY-130824	Bis-PEG10-NHS ester		≥95.0%	Unkown
HY-140759	Azido-PEG10-NHS ester		≥98.0%	Unkown
HY-126509	Mal-amido-PEG10-C2-NHS ester		95.23%	Unkown
HY-133231	Bis-PEG10-acid		≥98.0%	Unkown
HY-138726	Mal-PEG10-NHS ester		/	Unkown
HY-141218	m-PEG10-alcohol		≥97.0%	Unkown
HY-133304	HO-PEG10-CH2COOH		≥98.0%	Unkown
HY-139018	TLR7/8 agonist 4 hydroxy-PEG10-acid		/	Unkown
HY-139018A	TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride		/	Unkown
HY-120761	Amino-PEG10-OH		/	Unkown
HY-126508	Mal-amido-PEG5-C2-NHS ester		/	Unkown
HY-130424	m-PEG10-azide		/	Unkown
HY-132057	Bis-PEG10-t-butyl ester		/	Unkown
HY-132065	Decaethylene glycol dodecyl ether		99.91%	Unkown
HY-132076	Azido-PEG10-azide		/	Unkown
HY-132081	Benzyl-PEG10-t-butyl ester		/	Unkown
HY-132098	Bis-propargyl-PEG10		/	Unkown
HY-132118	Bromo-PEG10-t-butyl ester		/	Unkown
HY-133230	Propargyl-PEG10-amine		/	Unkown
HY-133270	m-PEG10-SH		/	Unkown
HY-133307	Hydroxy-PEG10-acid		99.59%	Unkown
HY-134718	Glycocholic acid-PEG10-iodoacetamide		/	Unkown
HY-134747	THP-PEG10-THP		/	Unkown
HY-135930	Boc-NH-PEG10-CH2CH2NH2		/	Unkown
HY-138316	THP-PEG10-C2-Boc		/	Unkown
HY-138341	Benzyl-PEG10-THP		/	Unkown
HY-138344	MS-PEG10-THP		/	Unkown
HY-138347	THP-PEG10-Boc		/	Unkown
HY-138350	Azido-PEG10-CH2CO2-NHS		/	Unkown
HY-138390	NH2-PEG10-C2-dimethylamino		/	Unkown
HY-138413	THP-PEG10-OH		/	Unkown
HY-138416	Azido-PEG10-CH2COOH		/	Unkown
HY-138460	Propargyl-PEG10-alcohol		/	Unkown
HY-138713	Benzyl-PEG10-Ots		/	Unkown
HY-138721	Fmoc-PEG10-NHS ester		/	Unkown
HY-138722	Mal-PEG10-Boc		/	Unkown
HY-138723	Mal-PEG10-acid		/	Unkown
HY-138739	Azido-PEG10-propargyl		/	Unkown
HY-140020	Propargyl-PEG10-acid		≥98.0%	Unkown
HY-140029	Propargyl-PEG10-Boc		/	Unkown
HY-140226	m-PEG10-amine		/	Unkown
HY-140304	DBCO-PEG10-DBCO		/	Unkown
HY-140360	m-PEG10-Tos		/	Unkown
HY-140455	Azido-PEG10-acid		/	Unkown
HY-140500	m-PEG10-acid		/	Unkown
HY-140781	Azido-PEG10-Boc		/	Unkown
HY-140801	Azido-PEG10-alcohol		/	Unkown
HY-140861	Trityl-PEG10-azide		/	Unkown
HY-140973	Mal-amido-PEG10-acid		/	Unkown
HY-141104	m-PEG10-NHS ester		/	Unkown
HY-141130	LG-PEG10-click-DBCO-Oleic		/	Unkown
HY-141399	m-PEG10-T-Butyl ester		/	Unkown
HY-143827	Biotin-PEG10-amine		/	Unkown
HY-143828	t-Boc-N-amido-PEG10-Br		/	Unkown
HY-143836	Acid-PEG10-t-butyl ester		/	Unkown
HY-143855	Biotin-PEG10-NHS ester		/	Unkown
HY-144076	t-Boc-amido-PEG10-acid		/	Unkown
HY-RS10318	PEG10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W019939	Hydroxy-PEG10-Boc		/	Unkown
HY-W096081	Benzyl-PEG10-alcohol		/	Unkown
HY-W190857	N-Boc-PEG10-alcohol		/	Unkown
HY-133335	Amino-PEG10-CH2-Boc		/	Unkown
HY-164654	DOTA-PEG10-azide		/	Unkown
HY-P10392AF	fStAx-35R TFA	Inhibitor	97.35%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PEG10	VGNC	VGNC:50004
Canis familiaris	PEG10	VGNC	VGNC:49685
Mus musculus	PEG10	MGD	MGI:2157785
Felis catus	PEG10	VGNC	VGNC:102657
Rattus norvegicus	PEG10	RGD	RGD:1595574

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