SARM1 - sterile alpha and TIR motif containing 1 Gene

Homo sapiens

Also known as SARM; HsTIR; SAMD2; hSARM1; MyD88-5

Gene ID: 23098 | Gene type: protein coding

About SARM1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,371,694-28,404,049 (from NCBI)

This gene has 8 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in duodenum (RPKM 30.5), small intestine (RPKM 14.6) and 23 other tissues.

Summary

Enables NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Involved in NAD catabolic process; positive regulation of neuron death; and response to axon injury. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SARM1 Products(1)

mRNA	Protein	Name
NM_015077.4	NP_055892.2	NAD(+) hydrolase SARM1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+ nucleosidase activity	IDA IDA: Inferred from direct assay	28334607	GOA
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IDA IDA: Inferred from direct assay	28334607	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	31439792	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17258210	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NAD catabolic process	IDA IDA: Inferred from direct assay	25908823	GOA
involved in response to axon injury	IDA IDA: Inferred from direct assay	25908823	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	22145856	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SARM1 Protein Structure

SAM_2

TIR_2

0
200
400
600
690 a.a.

Protein Preferred Names

Protein Names

NAD(+) hydrolase SARM1

NADP(+) hydrolase SARM1

Related Diseases

Diseases

Alias

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Wallerian Degeneration

Wallerian Degeneration Of The Pyramidal Tract

Bullous Retinoschisis

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0985	Phenazopyridine hydrochloride	Antagonist	99.84%	Unkown
HY-B0985A	Phenazopyridine	Antagonist	99.93%	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129522	Sulfo-ara-F-NMN	Activator	99.36%	Unkown
HY-W021879	DSRM-3716		99.86%	Unkown
HY-145917	SARM1-IN-2		99.34%	Unkown
HY-Z0816	Dehydronitrosonisoldipine	Antagonist	≥98.0%	Unkown
HY-161918	SARM1-IN-3		/	Unkown
HY-RS12446	SARM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W008341	5-Chloroisoquinoline	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SARM1	VGNC	VGNC:104648
Rattus norvegicus	SARM1	RGD	RGD:1310078
Mus musculus	SARM1	MGD	MGI:2136419
Bos taurus	SARM1	VGNC	VGNC:34290
Canis familiaris	SARM1	VGNC	VGNC:45868
Felis catus	SARM1	VGNC	VGNC:64875
Others	SARM1	NCBI

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