ATG2A - autophagy related 2A Gene

Homo sapiens

Also known as BLTP4A

Gene ID: 23130 | Gene type: protein coding

About ATG2A

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,894,546-64,917,209 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 17.3), spleen (RPKM 4.8) and 25 other tissues.

Summary

Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore assembly site. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATG2A Products(3)

mRNA	Protein	Name
NM_001367971.1	NP_001354900.1	autophagy-related protein 2 homolog A isoform 2
NM_001367972.1	NP_001354901.1	autophagy-related protein 2 homolog A isoform 3
NM_015104.3	NP_055919.2	autophagy-related protein 2 homolog A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipid transfer activity	IDA IDA: Inferred from direct assay	30952800	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	28561066	GOA
involved in positive regulation of autophagosome assembly	IDA IDA: Inferred from direct assay	30952800	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in organelle membrane contact site	IDA IDA: Inferred from direct assay	30952800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG2A Protein Structure

Chorein_N

ATG_C

0
300
600
900
1200
1500
1800
1938 a.a.

Protein Preferred Names

Protein Names

autophagy-related protein 2 homolog A

ATG2 autophagy related 2 homolog A

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Neurodegeneration With Brain Iron Accumulation 5

NBIA5	Beta-Propeller Protein-Associated Neurodegeneration
Bpan	Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood
Senda	Neurodegeneration With Brain Iron Accumulation Type 5
Neurodegeneration With Brain Iron Accululation 5	Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood
Neurodegeneration, With Brain Iron Accululation, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01145	ATG2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATG2A	VGNC	VGNC:60000
Rattus norvegicus	ATG2A	RGD	RGD:1589890
Bos taurus	ATG2A	VGNC	VGNC:106645
Macaca mulatta	ATG2A	VGNC	VGNC:70145
Canis familiaris	ATG2A	VGNC	VGNC:38221
Mus musculus	ATG2A	MGD	MGI:1916291

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