ATG9A - autophagy related 9A Gene

Homo sapiens

Also known as mATG9; APG9L1; MGD3208

Gene ID: 79065 | Gene type: protein coding

About ATG9A

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,219,380-219,229,636 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues and 1 paralogue. Broad expression in testis (RPKM 45.2), brain (RPKM 19.5) and 25 other tissues.

Summary

Acts upstream of or within autophagosome assembly. Located in endosome; phagophore assembly site; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

ATG9A Products(2)

mRNA	Protein	Name
NM_001077198.3	NP_001070666.1	autophagy-related protein 9A
NM_024085.5	NP_076990.4	autophagy-related protein 9A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	33106659	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19893488	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	29437695	GOA
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	15755735	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	29180427	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	34432599	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	27663665	GOA
NOT located in autophagosome membrane	IDA IDA: Inferred from direct assay	22456507	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	27316455	GOA
located in endosome	IDA IDA: Inferred from direct assay	23093945	GOA
located in late endosome	IDA IDA: Inferred from direct assay	22456507	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	34432599	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	22456507	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	22456507	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	29437695	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	22456507	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG9A Protein Structure

APG9

0
200
400
600
839 a.a.

Protein Preferred Names

Protein Names

autophagy-related protein 9A

APG9 autophagy 9-like 1

ATG9A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATG9A	Q7Z3C6	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	ATG9A	Q7Z3C6	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	ATG9A	Q7Z3C6	UBE3A	Homo sapiens	Q05086-2	Y2H Array	25416956
Intra	ATG9A	Q7Z3C6	UBE3A	Homo sapiens	Q05086-2	Y2H Prey Pooling	25416956
Intra	ATG9A	Q7Z3C6	AP2M1	Homo sapiens	Q96CW1	FPS	33436498
Intra	ATG9A	Q7Z3C6	AP2M1	Homo sapiens	Q96CW1	Pull Down	24603492
Intra	ATG9A	Q7Z3C6	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	ATG9A	Q7Z3C6	TBK1	Homo sapiens	Q9UHD2	Anti Tag CoIP	21903422
Intra	ATG9A	Q7Z3C6	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	ATG9A	Q7Z3C6	SUPT20H	Homo sapiens	Q8NEM7-2	Y2H	19893488
Intra	ATG9A	Q7Z3C6	SUPT20H	Homo sapiens	Q8NEM7-2	Anti Bait CoIP	19893488
Intra	ATG9A	Q7Z3C6	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	ATG9A	Q7Z3C6	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	ATG9A	Q7Z3C6	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

ATG9A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83336	ATG9A Antibody (YA3081)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Spastic Paraplegia 52, Autosomal Recessive

SPG52	Hereditary Spastic Paraplegia 52
Cpsq6	Cerebral Palsy, Spastic Quadriplegic, 6, Formerly
Cpsq6, Formerly	Autosomal Recessive Spastic Paraplegia 52
Spastic Quadriplegic Cerebral Palsy 6	Cerebral Palsy, Spastic Quadriplegic 6

Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50	SPG50
Ap-4 Deficiency Syndrome	Ap-4-Associated Hereditary Spastic Paraplegia
Adaptor Protein Complex 4 Deficiency	Cerebral Palsy, Spastic Quadriplegic, 3, Formerly
Cpsq3, Formerly	Autosomal Recessive Spastic Paraplegia 50
Cpsq3	Spastic Quadriplegic Cerebral Palsy 3
Ap-4 Deficiency	Ap-4-Associated Hsp
Paraplegia, Spastic, Autosomal Recessive, Type 50	Spastic Paraplegia-50, Autosomal Recessive

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01154	ATG9A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATG9A	VGNC	VGNC:80143
Macaca mulatta	ATG9A	VGNC	VGNC:81180
Canis familiaris	ATG9A	VGNC	VGNC:38228
Rattus norvegicus	ATG9A	RGD	RGD:1310450
Mus musculus	ATG9A	MGD	MGI:2138446
Bos taurus	ATG9A	VGNC	VGNC:26262

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