SMC5 - structural maintenance of chromosomes 5 Gene

Homo sapiens

Also known as SMC5L1

Gene ID: 23137 | Gene type: protein coding

About SMC5

Cytogenetic location: 9q21.12 Genomic coordinates (GRCh38): 9:70,258,978-70,354,873 (from NCBI)

This gene has 4 transcripts (splice variants), 120 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 12.4), lymph node (RPKM 10.1) and 25 other tissues.

Summary

Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC5 Products(1)

mRNA	Protein	Name
NM_015110.4	NP_055925.2	structural maintenance of chromosomes protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA secondary structure binding	IDA IDA: Inferred from direct assay	28095508	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11408570	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	11408570	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	17589526	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	16810316	GOA
NOT involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	16810316	GOA
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	28095508	GOA
involved in positive regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	25931565	GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	19502785	GOA
involved in telomere maintenance via recombination	IMP IMP: Inferred from mutant phenotype	17589526	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	17589526	GOA
part of Smc5-Smc6 complex	IDA IDA: Inferred from direct assay	18086888	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	17589526	GOA
located in interchromatin granule	IDA IDA: Inferred from direct assay	11408570	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	28095508	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11408570	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	25931565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMC5 Protein Structure

SMC_N

0
200
400
600
800
1000
1101 a.a.

Protein Preferred Names

Protein Names

structural maintenance of chromosomes protein 5

SMC protein 5

SMC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMC5	Q8IY18	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	SMC5	Q8IY18	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	SMC5	Q8IY18	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	SMC5	Q8IY18	SLF2	Homo sapiens	Q8IX21	BioID	36373674
Intra	SMC5	Q8IY18	SLF2	Homo sapiens	Q8IX21	Pull Down	32389690
Intra	SMC5	Q8IY18	SMC6	Homo sapiens	Q96SB8	Crosslink	32389690
Intra	SMC5	Q8IY18	SMC6	Homo sapiens	Q96SB8	BioID	36373674
Intra	SMC5	Q8IY18	SMC6	Homo sapiens	Q96SB8	Y2H	15601840

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13421	SMC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SMC5	RGD	RGD:1307492
Bos taurus	SMC5	VGNC	VGNC:35002
Canis familiaris	SMC5	VGNC	VGNC:46546
Felis catus	SMC5	VGNC	VGNC:65479
Mus musculus	SMC5	MGD	MGI:2385088

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