GSE1 - Gse1 coiled-coil protein Gene

Homo sapiens

Also known as CRHSP24; KIAA0182

Gene ID: 23199 | Gene type: protein coding

About GSE1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,169,512-85,676,200 (from NCBI)

This gene has 16 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in placenta (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast Cancer and enhanced expression of the encoded protein has been observed in breast Cancer patients. [provided by RefSeq, May 2017]

GSE1 Products(3)

mRNA	Protein	Name
NM_001134473.3	NP_001127945.1	genetic suppressor element 1 isoform 2
NM_001278184.3	NP_001265113.1	genetic suppressor element 1 isoform 3
NM_014615.5	NP_055430.1	genetic suppressor element 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSE1 Protein Structure

DUF3736

0
200
400
600
800
1000
1217 a.a.

Protein Preferred Names

Protein Names

genetic suppressor element 1

CTC-786C10.1

GSE1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GSE1	Q14687	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	GSE1	Q14687	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	GSE1	Q14687	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	GSE1	Q14687	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	GSE1	Q14687	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3	Y2H Pooling	16189514
Intra	GSE1	Q14687	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	GSE1	Q14687	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	25416956
Intra	GSE1	Q14687	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intraventricular Meningioma

Adult Medulloblastoma

Adult Brain Medulloblastoma

Medulloblastoma, Adult

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05859	GSE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GSE1	VGNC	VGNC:41527
Mus musculus	GSE1	MGD	MGI:1098275
Bos taurus	GSE1	VGNC	VGNC:55049
Macaca mulatta	GSE1	VGNC	VGNC:73254
Felis catus	GSE1	VGNC	VGNC:108362
Rattus norvegicus	GSE1	RGD	RGD:1562686

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