LENG8 - leukocyte receptor cluster member 8 Gene

Homo sapiens

Also known as pp13842

Gene ID: 114823 | Gene type: protein coding

About LENG8

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,449,199-54,462,016 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 188 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 65.5), endometrium (RPKM 49.9) and 24 other tissues.

Summary

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

LENG8 Products(6)

mRNA	Protein	Name
NM_001375638.1	NP_001362567.1	leukocyte receptor cluster member 8 isoform 1
NM_001375639.1	NP_001362568.1	leukocyte receptor cluster member 8 isoform 2
NM_001375640.1	NP_001362569.1	leukocyte receptor cluster member 8 isoform 1
NM_001375641.1	NP_001362570.1	leukocyte receptor cluster member 8 isoform 1
NM_001411063.1	NP_001397992.1	leukocyte receptor cluster member 8 isoform 4
NM_052925.4	NP_443157.1	leukocyte receptor cluster member 8 isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16239144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LENG8 Protein Structure

SAC3_GANP

0
200
400
600
800 a.a.

Protein Preferred Names

Protein Names

leukocyte receptor cluster member 8

leukocyte receptor cluster (LRC) member 8

LENG8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LENG8	Q96PV6	FAM22F	Homo sapiens	B7ZLH0	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	FAM22F	Homo sapiens	B7ZLH0	Y2H Array	32296183
Intra	LENG8	Q96PV6	PCID2	Homo sapiens	Q5JVF3	Y2H Array	32296183
Intra	LENG8	Q96PV6	PCID2	Homo sapiens	Q5JVF3	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	PER2	Homo sapiens	O15055	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	PER2	Homo sapiens	O15055	Y2H Array	32296183
Intra	LENG8	Q96PV6	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	LENG8	Q96PV6	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	LENG8	Q96PV6	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	LENG8	Q96PV6	CPSF7	Homo sapiens	Q8N684-3	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	CPSF7	Homo sapiens	Q8N684-3	Y2H Array	32296183
Intra	LENG8	Q96PV6	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	LENG8	Q96PV6	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
Intra	LENG8	Q96PV6	VGLL3	Homo sapiens	A8MV65-2	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	VGLL3	Homo sapiens	A8MV65-2	Y2H Array	32296183
Intra	LENG8	Q96PV6	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Array	32296183
Intra	LENG8	Q96PV6	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	LENG8	Q96PV6	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	LENG8	Q96PV6	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	LENG8	Q96PV6	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	SOCS7	Homo sapiens	O14512	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	SOCS7	Homo sapiens	O14512	Y2H Array	32296183
Intra	LENG8	Q96PV6	MIA3	Homo sapiens	Q5JRA6	Y2H Array	32296183
Intra	LENG8	Q96PV6	MIA3	Homo sapiens	Q5JRA6	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	LENG8	Q96PV6	TSG101	Homo sapiens	Q99816	Y2H Array	32296183
Intra	LENG8	Q96PV6	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	LENG8	Q96PV6	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	LENG8	Q96PV6	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	LENG8	Q96PV6	ANKHD1	Homo sapiens	Q8IWG5	Y2H Array	32296183
Intra	LENG8	Q96PV6	ANKHD1	Homo sapiens	Q8IWG5	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TFG	Homo sapiens	Q92734	Y2H Array	32296183
Intra	LENG8	Q96PV6	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	LENG8	Q96PV6	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	32296183
Intra	LENG8	Q96PV6	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	LENG8	Q96PV6	GSE1	Homo sapiens	Q14687	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	GSE1	Homo sapiens	Q14687	Y2H Array	32296183
Intra	LENG8	Q96PV6	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	LENG8	Q96PV6	COG2	Homo sapiens	Q14746	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	COG2	Homo sapiens	Q14746	Y2H Array	32296183
Intra	LENG8	Q96PV6	HNRNPM	Homo sapiens	P52272	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	HNRNPM	Homo sapiens	P52272	Y2H Array	32296183
Intra	LENG8	Q96PV6	MYOZ3	Homo sapiens	Q8TDC0	Y2H Array	32296183
Intra	LENG8	Q96PV6	MYOZ3	Homo sapiens	Q8TDC0	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	LENG8	Q96PV6	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
Intra	LENG8	Q96PV6	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	LENG8	Q96PV6	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	LENG8	Q96PV6	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	LENG8	Q96PV6	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	LENG8	Q96PV6	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	LENG8	Q96PV6	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	LENG8	Q96PV6	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	LENG8	Q96PV6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LENG8	Q96PV6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LENG8	Q96PV6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LENG8	Q96PV6	HMGXB4	Homo sapiens	Q9UGU5	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	HMGXB4	Homo sapiens	Q9UGU5	Validated Y2H	32296183
Intra	LENG8	Q96PV6	HMGXB4	Homo sapiens	Q9UGU5	Y2H Array	32296183
Intra	LENG8	Q96PV6	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	LENG8	Q96PV6	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Array	19060904
Intra	LENG8	Q96PV6	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Pooling	19060904
Intra	LENG8	Q96PV6	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Array	32296183
Intra	LENG8	Q96PV6	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	CFAP53	Homo sapiens	Q96M91	Y2H Array	32296183
Intra	LENG8	Q96PV6	CFAP53	Homo sapiens	Q96M91	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	LENG8	Q96PV6	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	LENG8	Q96PV6	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	LENG8	Q96PV6	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	LENG8	Q96PV6	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	LENG8	Q96PV6	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	LENG8	Q96PV6	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	LENG8	Q96PV6	IKBKG	Homo sapiens	Q9Y6K9	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	IKBKG	Homo sapiens	Q9Y6K9	Y2H Array	32296183
Intra	LENG8	Q96PV6	IKBKG	Homo sapiens	Q9Y6K9	Validated Y2H	32296183
Intra	LENG8	Q96PV6	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	LENG8	Q96PV6	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	LENG8	Q96PV6	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	LENG8	Q96PV6	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07591	LENG8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LENG8	MGD	MGI:2142195
Bos taurus	LENG8	VGNC	VGNC:30839
Rattus norvegicus	LENG8	RGD	RGD:1306180
Macaca mulatta	LENG8	VGNC	VGNC:74047
Canis familiaris	LENG8	VGNC	VGNC:42636
Felis catus	LENG8	VGNC	VGNC:63213

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