2. Gene
  3. KAZN - kazrin, periplakin interacting protein Gene

KAZN - kazrin, periplakin interacting protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KAZ; C1orf196

Gene ID: 23254 | Gene type: protein coding

About KAZN

Cytogenetic location: 1p36.21 Genomic coordinates (GRCh38): 1:13,892,824-15,118,043 (from NCBI)

This gene has 9 transcripts (splice variants) and 310 orthologues. Broad expression in spleen (RPKM 16.3), brain (RPKM 5.1) and 17 other tissues.

Summary

This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. [provided by RefSeq, Aug 2011]

KAZN Products(8)

mRNA Protein Name
NM_001017999.3 NP_001017999.1 kazrin isoform C
NM_001018000.4 NP_001018000.1 kazrin isoform B
NM_001018001.3 NP_001018001.1 kazrin isoform C
NM_001370229.1 NP_001357158.1 kazrin isoform F
NM_001370230.1 NP_001357159.1 kazrin isoform G
NM_001370231.1 NP_001357160.1 kazrin isoform H
NM_015209.2 NP_056024.1 kazrin isoform A
NM_201628.3 NP_963922.2 kazrin isoform E
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21653829 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cornified envelope IDA
IDA: Inferred from direct assay
15337775 GOA
located in desmosome IDA
IDA: Inferred from direct assay
15337775 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KAZN Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (444 - 508)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (530 - 583)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (609 - 666)

  • 0
  • 200
  • 400
  • 600
  • 775 a.a.
Protein Preferred Names Protein Names

kazrin

KAZN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KAZN Q674X7 TSC1 Homo sapiens Q92574
Anti Tag CoIP
21653829
Intra
KAZN Q674X7 TSC1 Homo sapiens Q92574
Y2H Pooling
21653829
Intra
KAZN Q674X7 FXR1 Homo sapiens P51114
Anti Tag CoIP
21653829
Intra
KAZN Q674X7 FXR1 Homo sapiens P51114
Y2H Pooling
21653829
Intra
KAZN Q674X7 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07090 KAZN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KAZN MGD MGI:1918779
Felis catus KAZN VGNC VGNC:107568
Bos taurus KAZN VGNC VGNC:30411
Rattus norvegicus KAZN RGD RGD:1359147
Canis familiaris KAZN VGNC VGNC:42221
Macaca mulatta KAZN VGNC VGNC:73932