2. Gene
  3. EXOC7 - exocyst complex component 7 Gene

EXOC7 - exocyst complex component 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BLOM4; EX070; EXO70; EXOC1; 2-5-3p; Exo70p; NEDSEBA; YJL085W

Gene ID: 23265 | Gene type: protein coding

About EXOC7

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,081,016-76,103,787 (from NCBI)

This gene has 21 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 23.4), brain (RPKM 22.0) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

EXOC7 Products(10)

mRNA Protein Name
NM_001013839.4 NP_001013861.1 exocyst complex component 7 isoform 1
NM_001145297.4 NP_001138769.1 exocyst complex component 7 isoform 4
NM_001145298.4 NP_001138770.1 exocyst complex component 7 isoform 5
NM_001145299.4 NP_001138771.1 exocyst complex component 7 isoform 6
NM_001282313.2 NP_001269242.1 exocyst complex component 7 isoform 3
NM_001282314.2 NP_001269243.1 exocyst complex component 7 isoform 7
NM_001375974.1 NP_001362903.1 exocyst complex component 7 isoform 8
NM_001375975.1 NP_001362904.1 exocyst complex component 7 isoform 9
NM_001375976.1 NP_001362905.1 exocyst complex component 7 isoform 10
NM_015219.5 NP_056034.2 exocyst complex component 7 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15705715 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
16148947 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of mitotic cytokinetic process IDA
IDA: Inferred from direct assay
16148947 GOA
involved in regulation of entry of bacterium into host cell IMP
IMP: Inferred from mutant phenotype
20579884 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
18000879 GOA
located in microtubule organizing center IDA
IDA: Inferred from direct assay
18000879 GOA
is active in midbody IDA
IDA: Inferred from direct assay
16148947 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOC7 Protein Structure

Exo70

Exo70: Exo70 exocyst complex subunit (364 - 730)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

exocyst complex component 7

exocyst complex component Exo70

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Seizures And Brain Atrophy

NEDSEBA
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04593 EXOC7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EXOC7 VGNC VGNC:28652
Felis catus EXOC7 VGNC VGNC:62004
Mus musculus EXOC7 MGD MGI:1859270
Rattus norvegicus EXOC7 RGD RGD:620236
Canis familiaris EXOC7 VGNC VGNC:40518
Macaca mulatta EXOC7 VGNC VGNC:72319