KXD1 - KxDL motif containing 1 Gene

Homo sapiens

Also known as KXDL; BORCS4; MST096; MSTP096; C10orf50; C19orf50

Gene ID: 79036 | Gene type: protein coding

About KXD1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,557,870-18,569,378 (from NCBI)

This gene has 17 transcripts (splice variants) and 166 orthologues. Ubiquitous expression in testis (RPKM 13.1), placenta (RPKM 13.1) and 25 other tissues.

Summary

Involved in lysosome localization. Part of BORC complex. [provided by Alliance of Genome Resources, Apr 2022]

KXD1 Products(3)

mRNA	Protein	Name
NM_001171948.2	NP_001165419.1	kxDL motif-containing protein 1
NM_001171949.2	NP_001165420.1	kxDL motif-containing protein 1
NM_024069.4	NP_076974.2	kxDL motif-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	25898167	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of BORC complex	IDA IDA: Inferred from direct assay	25898167	GOA
part of BORC complex	IPI IPI: Inferred from physical interaction	25898167	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KXD1 Protein Structure

KxDL

0
100
176 a.a.

Protein Preferred Names

Protein Names

kxDL motif-containing protein 1

BLOC-1 related complex subunit 4

KXD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KXD1	Q9BQD3	TPM3	Homo sapiens	Q5VU62	Y2H Array	25416956
Intra	KXD1	Q9BQD3	BORCS6	Homo sapiens	Q96GS4	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	TPM1	Homo sapiens	P09493-5	Y2H Array	25416956
Intra	KXD1	Q9BQD3	EXOC1	Homo sapiens	Q9NV70	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	KXD1	Q9BQD3	HAUS1	Homo sapiens	Q96CS2	Y2H Array	25416956
Intra	KXD1	Q9BQD3	LRRC45	Homo sapiens	Q96CN5	Y2H Array	31515488
Intra	KXD1	Q9BQD3	LRRC45	Homo sapiens	Q96CN5	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	LRRC45	Homo sapiens	Q96CN5	Y2H Array	25416956
Intra	KXD1	Q9BQD3	TPM1	Homo sapiens	P09493	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	TPM1	Homo sapiens	P09493	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	TPM3	Homo sapiens	P06753	Y2H Array	25416956
Intra	KXD1	Q9BQD3	TPM3	Homo sapiens	P06753	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	RPL9	Homo sapiens	P32969	Y2H Array	25416956
Intra	KXD1	Q9BQD3	RPL9	Homo sapiens	P32969	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	MAP1LC3B	Homo sapiens	Q9GZQ8	Validated Y2H	25416956
Intra	KXD1	Q9BQD3	MAP1LC3B	Homo sapiens	Q9GZQ8	Y2H Pooling	16189514
Intra	KXD1	Q9BQD3	ING5	Homo sapiens	Q8WYH8	Y2H Pooling	16189514
Intra	KXD1	Q9BQD3	MYH7	Homo sapiens	P12883	Validated Y2H	25416956
Intra	KXD1	Q9BQD3	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
Intra	KXD1	Q9BQD3	C4orf46	Homo sapiens	Q504U0	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	EXOC7	Homo sapiens	Q9UPT5	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	MAP1LC3A	Homo sapiens	Q9H492	Validated Y2H	32296183
Intra	KXD1	Q9BQD3	MAP1LC3A	Homo sapiens	Q9H492	Y2H Array	25416956
Intra	KXD1	Q9BQD3	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Intra	KXD1	Q9BQD3	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	CEP19	Homo sapiens	Q96LK0	Y2H Array	25416956
Intra	KXD1	Q9BQD3	CEP19	Homo sapiens	Q96LK0	Y2H Pooling	16189514
Intra	KXD1	Q9BQD3	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	CEP19	Homo sapiens	Q96LK0	Validated Y2H	25416956
Intra	KXD1	Q9BQD3	IFT20	Homo sapiens	Q8IY31	Validated Y2H	25416956
Intra	KXD1	Q9BQD3	IFT20	Homo sapiens	Q8IY31	Y2H Array	25416956
Intra	KXD1	Q9BQD3	IFT20	Homo sapiens	Q8IY31	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	IFT20	Homo sapiens	Q8IY31	Y2H Pooling	16189514
Intra	KXD1	Q9BQD3	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	KXD1	Q9BQD3	ZC4H2	Homo sapiens	Q9NQZ6	Anti Tag CoIP	33961781
Intra	KXD1	Q9BQD3	MOB1A	Homo sapiens	Q9H8S9	Y2H Pooling	16189514
Intra	KXD1	Q9BQD3	MOB1A	Homo sapiens	Q9H8S9	Validated Y2H	32296183
Intra	KXD1	Q9BQD3	DYRK2	Homo sapiens	Q92630	Validated Y2H	25416956
Intra	KXD1	Q9BQD3	DYRK2	Homo sapiens	Q92630	Y2H Prey Pooling	25416956
Intra	KXD1	Q9BQD3	EXOC5	Homo sapiens	O00471	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07478	KXD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KXD1	VGNC	VGNC:80608
Mus musculus	KXD1	MGD	MGI:1922870
Rattus norvegicus	KXD1	RGD	RGD:1562866
Canis familiaris	KXD1	VGNC	VGNC:42551
Bos taurus	KXD1	VGNC	VGNC:30757

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