2. Gene
  3. SSC5D - scavenger receptor cysteine rich family member with 5 domains Gene

SSC5D - scavenger receptor cysteine rich family member with 5 domains Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as S5D-SRCRB

Gene ID: 284297 | Gene type: protein coding

About SSC5D

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,488,436-55,519,099 (from NCBI)

This gene has 5 transcripts (splice variants), 397 orthologues and 15 paralogues. Broad expression in gall bladder (RPKM 7.3), endometrium (RPKM 6.2) and 21 other tissues.

Summary

Predicted to enable fibronectin binding activity; laminin binding activity; and scavenger receptor activity. Predicted to be involved in defense response; detection of Bacterial lipoprotein; and negative regulation of interleukin-8 production. Predicted to act upstream of or within regulation of interleukin-8 production. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SSC5D Products(2)

mRNA Protein Name
NM_001144950.2 NP_001138422.1 soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform 1 precursor
NM_001195267.2 NP_001182196.1 soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform 2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSC5D Protein Structure

SRCR

SRCR: Scavenger receptor cysteine-rich domain (24 - 119)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (201 - 298)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (308 - 403)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (470 - 568)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (776 - 872)

  • 0
  • 300
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  • 1200
  • 1573 a.a.
Protein Preferred Names Protein Names

soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

scavenger receptor cysteine rich domain containing (5 domains)

SSC5D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SSC5D A1L4H1 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
32296183
Intra
SSC5D A1L4H1 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
SSC5D A1L4H1 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra
SSC5D A1L4H1 SEC23IP Homo sapiens Q9Y6Y8
Validated Y2H
25416956
Intra
SSC5D A1L4H1 SEC23IP Homo sapiens Q9Y6Y8
Y2H Prey Pooling
25416956
Intra
SSC5D A1L4H1 SEC23IP Homo sapiens Q9Y6Y8
Validated Y2H
32296183
Intra
SSC5D A1L4H1 SEC23IP Homo sapiens Q9Y6Y8
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 SEC23IP Homo sapiens Q9Y6Y8
Y2H Array
32296183
Intra
SSC5D A1L4H1 HAUS1 Homo sapiens Q96CS2
Validated Y2H
32296183
Intra
SSC5D A1L4H1 HAUS1 Homo sapiens Q96CS2
Y2H Array
32296183
Intra
SSC5D A1L4H1 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
SSC5D A1L4H1 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
SSC5D A1L4H1 NUP62 Homo sapiens P37198
Validated Y2H
25416956
Intra
SSC5D A1L4H1 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 NUP62 Homo sapiens P37198
Validated Y2H
32296183
Intra
SSC5D A1L4H1 NUP62 Homo sapiens P37198
Y2H Array
32296183
Intra
SSC5D A1L4H1 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
SSC5D A1L4H1 MED29 Homo sapiens Q9NX70
Validated Y2H
32296183
Intra
SSC5D A1L4H1 MED29 Homo sapiens Q9NX70
Y2H Array
32296183
Intra
SSC5D A1L4H1 MED21 Homo sapiens Q13503
Validated Y2H
32296183
Intra
SSC5D A1L4H1 MED21 Homo sapiens Q13503
Y2H Array
32296183
Intra
SSC5D A1L4H1 MED21 Homo sapiens Q13503
Y2H Prey Pooling
25416956
Intra
SSC5D A1L4H1 MED21 Homo sapiens Q13503
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 MED11 Homo sapiens Q9P086
Y2H Array
32296183
Intra
SSC5D A1L4H1 MED11 Homo sapiens Q9P086
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 MED11 Homo sapiens Q9P086
Validated Y2H
32296183
Intra
SSC5D A1L4H1 DTNBP1 Homo sapiens Q96EV8
Validated Y2H
25416956
Intra
SSC5D A1L4H1 BLOC1S2 Homo sapiens Q6QNY1
Validated Y2H
32296183
Intra
SSC5D A1L4H1 BLOC1S2 Homo sapiens Q6QNY1
Y2H Array
32296183
Intra
SSC5D A1L4H1 BLOC1S2 Homo sapiens Q6QNY1
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 EXOC7 Homo sapiens Q9UPT5-1
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 EXOC7 Homo sapiens Q9UPT5-1
Validated Y2H
32296183
Intra
SSC5D A1L4H1 EXOC7 Homo sapiens Q9UPT5-1
Y2H Array
32296183
Intra
SSC5D A1L4H1 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra
SSC5D A1L4H1 PIN1 Homo sapiens Q13526
Validated Y2H
32296183
Intra
SSC5D A1L4H1 EXOC7 Homo sapiens Q9UPT5
Y2H Prey Pooling
25416956
Intra
SSC5D A1L4H1 SDCBP Homo sapiens O00560
Validated Y2H
32296183
Intra
SSC5D A1L4H1 SKA1 Homo sapiens Q96BD8
Y2H Prey Pooling
32296183
Intra
SSC5D A1L4H1 SKA1 Homo sapiens Q96BD8
Y2H Array
32296183
Intra
SSC5D A1L4H1 SKA1 Homo sapiens Q96BD8
Validated Y2H
32296183
Intra
SSC5D A1L4H1 CEP170P1 Homo sapiens Q96L14
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nasal Type Extranodal Nk/T-Cell Lymphoma

Extranodal Nasal Nk/T Cell Lymphoma

Angiocentric T-Cell Lymphoma

Lethal Midline Granuloma

Nk/T-Cell Lymphoma

Nktcl

Nasal T/Natural Killer-Cell Lymphoma

Granuloma, Lethal Midline

Nasal And Nasal-Type Nk/T-Cell Lymphoma
Adenoiditis

Chronic Adenoiditis
Vitreous Detachment

Posterior Vitreous Detachment

Vitreous Syneresis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13808 SSC5D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SSC5D VGNC VGNC:53993
Felis catus SSC5D VGNC VGNC:82391
Mus musculus SSC5D MGD MGI:3606211
Rattus norvegicus SSC5D RGD RGD:1565772
Bos taurus SSC5D VGNC VGNC:35310