WBP2 - WW domain binding protein 2 Gene

Homo sapiens

Also known as WBP-2; GRAMD6; DFNB107

Gene ID: 23558 | Gene type: protein coding

About WBP2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,845,699-75,856,436 (from NCBI)

This gene has 19 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 118.9), adrenal (RPKM 61.3) and 25 other tissues.

Summary

The globular WW domain is composed of 38 to 40 semiconserved Amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of Estrogen Receptor alpha and Progesterone Receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]

WBP2 Products(3)

mRNA	Protein	Name
NM_001330499.2	NP_001317428.1	WW domain-binding protein 2 isoform 2
NM_001348170.1	NP_001335099.1	WW domain-binding protein 2 isoform 1
NM_012478.4	NP_036610.2	WW domain-binding protein 2 isoform 1

WBP2 Protein Structure

GRAM

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

WW domain-binding protein 2

Recombinant WBP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71431	WBP2 Protein, Human (His)	Q969T9-1 (M1-A100)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 107

DFNB107

Deafness, Autosomal Recessive, 107

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15750	WBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15751	WBP2NL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WBP2	MGD	MGI:104709
Rattus norvegicus	WBP2	RGD	RGD:620032
Macaca mulatta	WBP2	VGNC	VGNC:78786
Canis familiaris	WBP2	VGNC	VGNC:48341
Bos taurus	WBP2	VGNC	VGNC:36872
Felis catus	WBP2	VGNC	VGNC:99573
Others	WBP2	NCBI

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