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  2. WBP2 - WW domain binding protein 2 Gene

WBP2 - WW domain binding protein 2 Gene

Homo sapiens

Also known as WBP-2; GRAMD6; DFNB107

Gene ID: 23558 | Gene type: protein coding

About WBP2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,845,699-75,856,436 (from NCBI)

This gene has 19 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 118.9), adrenal (RPKM 61.3) and 25 other tissues.

Summary

The globular WW domain is composed of 38 to 40 semiconserved Amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of Estrogen Receptor alpha and Progesterone Receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]

WBP2 Products(3)

mRNA Protein Name
NM_001330499.2 NP_001317428.1 WW domain-binding protein 2 isoform 2
NM_001348170.1 NP_001335099.1 WW domain-binding protein 2 isoform 1
NM_012478.4 NP_036610.2 WW domain-binding protein 2 isoform 1

WBP2 Protein Structure

GRAM

GRAM: GRAM domain (6 - 84)

(100 - 204)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

WW domain-binding protein 2

Recombinant WBP2 Proteins

Cat. No. Product Name Accession Purity
HY-P71431 WBP2 Protein, Human (His) Q969T9-1 (M1-A100) ≥95%

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 107

DFNB107

Deafness, Autosomal Recessive, 107

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb

Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb

Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus WBP2 MGD MGI:104709
Rattus norvegicus WBP2 RGD RGD:620032
Macaca mulatta WBP2 VGNC VGNC:78786
Canis familiaris WBP2 VGNC VGNC:48341
Bos taurus WBP2 VGNC VGNC:36872
Felis catus WBP2 VGNC VGNC:99573
Others WBP2 NCBI