2. Gene
  3. ZNF346 - zinc finger protein 346 Gene

ZNF346 - zinc finger protein 346 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as JAZ; Zfp346

Gene ID: 23567 | Gene type: protein coding

About ZNF346

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:177,022,696-177,081,189 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 9 paralogues. Ubiquitous expression in ovary (RPKM 2.4), thyroid (RPKM 2.2) and 25 other tissues.

Summary

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

ZNF346 Products(10)

mRNA Protein Name
NM_001308213.2 NP_001295142.1 zinc finger protein 346 isoform b
NM_001308214.2 NP_001295143.1 zinc finger protein 346 isoform c
NM_001308215.2 NP_001295144.1 zinc finger protein 346 isoform d
NM_001308216.2 NP_001295145.1 zinc finger protein 346 isoform e
NM_001308218.2 NP_001295147.1 zinc finger protein 346 isoform f
NM_001308219.2 NP_001295148.1 zinc finger protein 346 isoform g
NM_001308221.2 NP_001295150.1 zinc finger protein 346 isoform h
NM_001308223.2 NP_001295152.1 zinc finger protein 346 isoform h
NM_001363713.2 NP_001350642.1 zinc finger protein 346 isoform i
NM_012279.4 NP_036411.1 zinc finger protein 346 isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
10488071 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables miRNA binding IDA
IDA: Inferred from direct assay
28431233 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
10488071 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10488071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF346 Protein Structure

zf-met

zf-met: Zinc-finger of C2H2 type (74 - 97)

zf-met

zf-met: Zinc-finger of C2H2 type (136 - 158)

zf-met

zf-met: Zinc-finger of C2H2 type (186 - 209)

zf-met

zf-met: Zinc-finger of C2H2 type (241 - 263)

  • 0
  • 100
  • 200
  • 294 a.a.
Protein Preferred Names Protein Names

zinc finger protein 346

double-stranded RNA-binding zinc finger protein JAZ

ZNF346 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZNF346 Q9UL40 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
ZNF346 Q9UL40 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
ZNF346 Q9UL40 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
ZNF346 Q9UL40 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
Intra
ZNF346 Q9UL40 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
Intra
ZNF346 Q9UL40 KAT5 Homo sapiens Q92993
Y2H Array
32814053
Intra
ZNF346 Q9UL40 EIF2AK2 Homo sapiens P19525
Anti Tag CoIP
21903422
Intra
ZNF346 Q9UL40 NKRF Homo sapiens O15226
Anti Tag CoIP
33961781
Intra
ZNF346 Q9UL40 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
ZNF346 Q9UL40 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Intra
ZNF346 Q9UL40 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
ZNF346 Q9UL40 TARBP2 Homo sapiens Q15633
Y2H Prey Pooling
25416956
Intra
ZNF346 Q9UL40 TARBP2 Homo sapiens Q15633
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome

Aarrs

Limb/Pelvis-Hypoplasia/Aplasia Syndrome

LPHAS

Schinzel Type Phocomelia

Absence Of Ulna And Fibula With Severe Limb Deficiency

Al-Awadi/Raas-Rothschild Syndrome

Al Awadi-Raas-Rothschild Syndrome

Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

Aplasia/Hypoplasia Of Limbs And Pelvis

Congenital Absence Of Ulna And Fibula

Severe Limb Deficit

Phocomelia, Schinzel Type

Al-Awadi-Raas-Rothschild Syndrome

Ulna And Fibula Absence Of With Severe Limb Deficiency

Limb Pelvis Hypoplasia Aplasia Syndrome

Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Mite Infestation

Mite Infestations

Acariasis

Infestation By Mites Nos
Arthrogryposis Multiplex Congenita 2, Neurogenic Type

Arthrogryposis Multiplex Congenita, Neurogenic Type

Amcn

Arthrogryposis Multiplex Congenita Neurogenic Type

AMC2

Amc, Neurogenic Type

Neurogenic-Type Arthrogryposis Multiplex Congenita-2

Amc Neurogenic Type

Neurogenic Type Of Amc

Neurogenic Arthrogryposis Multiplex Congenita

Arthrogryposis Multiplex Congenita, Neurogenic
Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3

FASPS3

Familial Advanced Sleep Phase Syndrome 3

Sleep Phase Syndrome, Advanced, Familial, Type 3
Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism
Phenylketonuria

Phenylalanine Hydroxylase Deficiency

PKU

Pah Deficiency

Folling Disease

Maternal Phenylketonuria

Phenylketonurias

Oligophrenia Phenylpyruvica

Hyperphenylalaninemia, Non-Pku Mild

Folling'S Disease

Phenylalaninemia

Mild Phenylketonuria

Mild Pku

Variant Pku

Variant Phenylketonuria

Mpku

Deficiency Disease, Phenylalanine Hydroxylase

Phenylketonuria, Maternal

Phenylalanine Hydroxylase Deficiency Disease

Hyperphenylalaninemic Embryopathy

Maternal Pku

Maternal Hyperphenylalaninemia

Phenylketonuric Embryopathy

Hyperphenylalaninemia

HPA

Non-Phenylketonuria Hyperphenylalaninemia

NON-PKU HPA

Phenylketonuria Maternal

Classical Phenylketonuria

Hyperphenylalaninaemia

Pku - [Phenylketonuria]
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome

WTS

Mrxs6

X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome

Mrxswt

Wilson-Turner X-Linked Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic 6

Mental Retardation, X-Linked, With Gynecomastia And Obesity

Intellectual Disability, X-Linked, Syndromic 6

Intellectual Disability, X-Linked, With Gynecomastia And Obesity

Wilson Turner Intellectual Disability Syndrome

X-Linked Intellectual Disability - Gynecomastia - Obesity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16129 ZNF346 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZNF346 VGNC VGNC:79034
Rattus norvegicus ZNF346 RGD RGD:1308068
Bos taurus ZNF346 VGNC VGNC:37254
Felis catus ZNF346 VGNC VGNC:102370
Canis familiaris ZNF346 VGNC VGNC:48706
Mus musculus ZNF346 MGD MGI:1349417