2. Gene
  3. ZIM2 - zinc finger imprinted 2 Gene

ZIM2 - zinc finger imprinted 2 Gene

  • Gene
  • Protein
  • Agent
Homo sapiens

Also known as ZNF656

Gene ID: 23619 | Gene type: protein coding

About ZIM2

This gene has 11 transcripts (splice variants), 13 orthologues and 174 paralogues. Biased expression in ovary (RPKM 34.2), placenta (RPKM 19.3) and 4 other tissues.

Summary

In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]

ZIM2 Products(11)

mRNA Protein Name
NM_001146326.2 NP_001139798.1 zinc finger imprinted 2 isoform b
NM_001146327.2 NP_001139799.1 zinc finger imprinted 2 isoform b
NM_001369770.1 NP_001356699.1 zinc finger imprinted 2 isoform b
NM_001369771.1 NP_001356700.1 zinc finger imprinted 2 isoform b
NM_001369772.1 NP_001356701.1 zinc finger imprinted 2 isoform b
NM_001369773.1 NP_001356702.1 zinc finger imprinted 2 isoform a
NM_001369774.1 NP_001356703.1 zinc finger imprinted 2 isoform a
NM_001387356.1 NP_001374285.1 zinc finger imprinted 2 isoform a
NM_001387357.1 NP_001374286.1 zinc finger imprinted 2 isoform b
NM_001387358.1 NP_001374287.1 zinc finger imprinted 2 isoform b
NM_015363.5 NP_056178.3 zinc finger imprinted 2 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZIM2 Protein Structure

KRAB

KRAB: KRAB box (176 - 216)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (342 - 366)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (412 - 434)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (483 - 504)

  • 0
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  • 400
  • 527 a.a.
Protein Preferred Names Protein Names

zinc finger imprinted 2

zinc finger protein 656

ZIM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZIM2 Q9NZV7 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
ZIM2 Q9NZV7 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 LIMS1 Homo sapiens P48059-3
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 LIMS1 Homo sapiens P48059-3
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 ZNF383 Homo sapiens Q8NA42
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 ZNF383 Homo sapiens Q8NA42
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra
ZIM2 Q9NZV7 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra
ZIM2 Q9NZV7 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16079 ZIM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown