2. Gene
  3. BLZF1 - basic leucine zipper nuclear factor 1 Gene

BLZF1 - basic leucine zipper nuclear factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as JEM1; JEM-1; JEM-1s; GOLGIN-45

Gene ID: 8548 | Gene type: protein coding

About BLZF1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,368,195-169,396,575 (from NCBI)

This gene has 5 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 12.9), esophagus (RPKM 10.8) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Acts upstream of or within Golgi organization and Golgi to plasma membrane protein transport. Located in Golgi apparatus and nucleoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

BLZF1 Products(3)

mRNA Protein Name
NM_001320972.2 NP_001307901.1 golgin-45 isoform 2
NM_001320973.2 NP_001307902.1 golgin-45 isoform 1
NM_003666.4 NP_003657.1 golgin-45 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
21478859 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21478859 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Golgi organization IDA
IDA: Inferred from direct assay
11739401 GOA
acts upstream of or within Golgi to plasma membrane protein transport IDA
IDA: Inferred from direct assay
11739401 GOA
Cellular Component GO Annotation Evidence Reference Source
NOT located in nucleus IDA
IDA: Inferred from direct assay
11739401 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9129147 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLZF1 Protein Structure

DASH_Hsk3

DASH_Hsk3: DASH complex subunit Hsk3 like (181 - 226)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

golgin-45

JEM-1short protein

BLZF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BLZF1 Q9H2G9 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 AMOTL2 Homo sapiens Q9Y2J4-4
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 IQUB Homo sapiens Q8NA54
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 VPS28 Homo sapiens Q548N1
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 FBF1 Homo sapiens Q8TES7-6
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 FBF1 Homo sapiens Q8TES7-6
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 TSC22D4 Homo sapiens Q8IV54
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 OAZ3 Homo sapiens Q9UMX2
Y2H Array
31515488
Intra
BLZF1 Q9H2G9 OAZ3 Homo sapiens Q9UMX2
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 OAZ3 Homo sapiens Q9UMX2
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 PRKAB2 Homo sapiens O43741
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 PRKAB2 Homo sapiens O43741
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 TRAPPC2L Homo sapiens Q9UL33-2
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 FAM124B Homo sapiens Q9H5Z6-2
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 PCDHB12 Homo sapiens Q9Y5F1
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 SSX2 Homo sapiens Q16385
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 SSX2 Homo sapiens Q16385
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 SSX2 Homo sapiens Q16385
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
BLZF1 Q9H2G9 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
BLZF1 Q9H2G9 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
BLZF1 Q9H2G9 TXNDC5 Homo sapiens Q86UY0
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 TBC1D7 Homo sapiens Q9P0N9
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 ZGPAT Homo sapiens Q8N5A5
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 SMAD3 Homo sapiens P84022
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 SMAD3 Homo sapiens P84022
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
BLZF1 Q9H2G9 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
BLZF1 Q9H2G9 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
BLZF1 Q9H2G9 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
BLZF1 Q9H2G9 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
BLZF1 Q9H2G9 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
BLZF1 Q9H2G9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
BLZF1 Q9H2G9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
BLZF1 Q9H2G9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
BLZF1 Q9H2G9 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 RAB2B Homo sapiens Q8WUD1
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 RAB2B Homo sapiens Q8WUD1
Y2H Array
32296183
Intra
BLZF1 Q9H2G9 RAB2B Homo sapiens Q8WUD1
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 RHOJ Homo sapiens Q9H4E5
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 FHL2 Homo sapiens Q14192
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 FHL2 Homo sapiens Q14192
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 ZNF410 Homo sapiens Q86VK4
Y2H Array
20211142
Intra
BLZF1 Q9H2G9 ZNF410 Homo sapiens Q86VK4
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 ZNF410 Homo sapiens Q86VK4
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 ZNF410 Homo sapiens Q86VK4
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 GORASP2 Homo sapiens Q9H8Y8
Anti Tag CoIP
33961781
Intra
BLZF1 Q9H2G9 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 CINP Homo sapiens Q9BW66
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 CINP Homo sapiens Q9BW66
Y2H Array
31515488
Intra
BLZF1 Q9H2G9 CINP Homo sapiens Q9BW66
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 HOXA1 Homo sapiens P49639
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 TCF19 Homo sapiens Q9Y242
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
Intra
BLZF1 Q9H2G9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
Intra
BLZF1 Q9H2G9 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
Intra
BLZF1 Q9H2G9 FRMD6 Homo sapiens Q96NE9
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 FRMD6 Homo sapiens Q96NE9
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 CHCHD3 Homo sapiens Q9NX63
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 CHCHD3 Homo sapiens Q9NX63
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 GEM Homo sapiens P55040
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 BEX2 Homo sapiens Q9BXY8
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 TRAPPC2L Homo sapiens Q9UL33
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 SCNM1 Homo sapiens Q9BWG6
Y2H Array
32296183
Intra
BLZF1 Q9H2G9 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 CARD9 Homo sapiens Q9H257
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 RAB2A Homo sapiens P61019
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 RAB2A Homo sapiens P61019
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 RAB2A Homo sapiens P61019
Y2H Prey Pooling
25416956
Intra
BLZF1 Q9H2G9 BCL6 Homo sapiens P41182
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 BCL6 Homo sapiens P41182
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 LMO1 Homo sapiens P25800
Validated Y2H
25416956
Intra
BLZF1 Q9H2G9 LMO1 Homo sapiens P25800
Y2H Array
25416956
Intra
BLZF1 Q9H2G9 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra
BLZF1 Q9H2G9 AKAP9 Homo sapiens Q99996-2
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Paraneoplastic Cerebellar Degeneration

Pcd

Paraneoplastic Cerebellar Ataxia

Rapidely Progressive Cerebellar Syndrome

Subacute Cerebellar Degeneration
Lissencephaly, X-Linked, 1

Lissencephaly Type 1 Due To Doublecortin Gene Mutation

Xlis

Lissencephaly, X-Linked

LISX1

Lissencephaly And Agenesis Of Corpus Callosum

Subcortical Laminal Heterotopia, X-Linked

X-Linked Lissencephaly 1

X-Linked Lissencephaly

Double Cortex

Xlis1

Lissencephaly X-Linked

Lisx

X-Linked Lissencephaly Type 1

Lissencephaly, X-Linked 1

Subcortical Band Heterotopia X-Linked

SBHX

Sclh

Subcortical Laminar Heterotopia

Lissencephaly, X-Linked, Type 1

Subcortical Band Heterotopia
Brucellosis

Mediterranean Fever

Malta Fever

Undulant Fever

Gibraltar Fever

Bang'S Disease

Maltese Fever

Cyprus Fever

Rock Fever

Brucellosis Infection

Brucella Infection
Cryptococcosis

Cryptococcus Neoformans Infection

Torulosis

Busse-Buschke'S Disease

Cryptococcal Infection

European Cryptococcosis

Torula

Infection By Cryptococcus Neoformans

Cryptococcosis Infection

European Blastomycosis

European Blastomycotic Infection

European Blastomycoses Infection

Torula Histolytica Infection
Alexander Disease

Alexander'S Disease

ALXDRD

Alexanders Leukodystrophy

Axd

Demyelinogenic Leukodystrophy

Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia

Alx

Dysmyelinogenic Leukodystrophy

Fibrinoid Degeneration Of Astrocytes

Leukodystrophy With Rosenthal Fibers

Alexander Disease Type Ii

Axd Type Ii

Alexander Disease Type I

Axd Type I

Alexanders Disease

Alexander'S Leukodystrophy
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01528 BLZF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BLZF1 MGD MGI:1201607
Felis catus BLZF1 VGNC VGNC:60127
Macaca mulatta BLZF1 VGNC VGNC:70258
Bos taurus BLZF1 VGNC VGNC:26512
Rattus norvegicus BLZF1 RGD RGD:1562452
Canis familiaris BLZF1 VGNC VGNC:38473