Ccl19 - chemokine (C-C motif) ligand 19 Gene

Mus musculus

Also known as ELC; CKb11; MIP3B; Gm2023; Scya19; exodus-3

Gene ID: 24047 | Gene type: protein coding

About Ccl19

Summary

Enables CCR7 Chemokine Receptor binding activity and chemokine activity. Involved in several processes, including positive regulation of T cell activation; positive regulation of cellular component organization; and positive regulation of cytokine production. Located in external side of plasma membrane. Is expressed in Peyer's patch; inguinal lymph node; thymus; and thymus primordium. Orthologous to human CCL19 (C-C motif chemokine ligand 19). [provided by Alliance of Genome Resources, Apr 2022]

Ccl19 Products(1)

mRNA	Protein	Name
NM_011888.4	NP_036018.1	C-C motif chemokine 19 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR7 chemokine receptor binding	IPI IPI: Inferred from physical interaction	9507024	MGI
enables chemokine activity	IDA IDA: Inferred from direct assay	12200351	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell costimulation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in cell maturation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in dendritic cell chemotaxis	IDA IDA: Inferred from direct assay	12200351	MGI
involved in immunological synapse formation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in mature conventional dendritic cell differentiation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	12609829	MGI
acts upstream of positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	16027136	MGI
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in positive regulation of T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	15845453	MGI
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	9507024	MGI
involved in positive regulation of dendritic cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	15845453	MGI
involved in positive regulation of dendritic cell dendrite assembly	IDA IDA: Inferred from direct assay	12200351	MGI
involved in positive regulation of endocytosis	IDA IDA: Inferred from direct assay	16027136	MGI
involved in positive regulation of glycoprotein biosynthetic process	IDA IDA: Inferred from direct assay	15845453	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15845453	MGI
acts upstream of positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15845453	MGI
involved in positive regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	12609829	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15845453	MGI
involved in regulation of cell projection assembly	IDA IDA: Inferred from direct assay	12200351	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19008373	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-C motif chemokine 19

EBI-1 ligand chemokine	EBI1 ligand chemokine
EBV-induced molecule 1 ligand chemokine	chemokine CCL19
epstein-Barr virus-induced molecule 1 ligand chemokine	small-inducible cytokine A19

Recombinant Ccl19 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7264	MIP-3 beta/CCL19 Protein, Mouse	O70460 (G26-S108)	≥95%
HY-P7264A	MIP-3 beta/CCL19 Protein, Mouse (sf9, His)	O70460 (G26-S108)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133073	CCR7 Ligand 1	Antagonist	99.62%	Unkown
HY-120427	Cosalane		99.78%	Unkown
HY-RS02088	CCL19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccl19	NCBI	NCBI:6363

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