Grm5 - glutamate metabotropic receptor 5 Gene

Rattus norvegicus

Also known as mGluR5; mGlur5

Gene ID: 24418 | Gene type: protein coding

About Grm5

Primary_assembly 1: 141,312,368-141,882,274 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 11 phenotypes. Restricted expression toward (RPKM 246.3).

Summary

Enables A2A Adenosine Receptor binding activity; glutamate receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and trans-synaptic signaling. Located in astrocyte projection; dendrite; and postsynaptic density membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 Products(1)

mRNA	Protein	Name
NM_017012.2	NP_058708.1	metabotropic glutamate receptor 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables A2A adenosine receptor binding	IPI IPI: Inferred from physical interaction	12189203	RGD
enables glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	1320017	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12189203	RGD
enables protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	24012003	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	24012003	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	1320017	RGD
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12514208	RGD
involved in desensitization of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12514208	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15758184	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	12740378	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15758184	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12189203	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	21753079	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	18582438	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	18582438	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8758956	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	15829628	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15829628	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	8758956	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm5 Protein Structure

PBP1_mGluR_groupI

NCD3G

7tmC_mGluR5

Herpes_BLLF1

GluR_Homer-bdg

0
200
400
600
800
1000
1203 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 5

glutamate receptor, metabotropic 5	metabotropic glutamate receptor (mGluR5)
metabotropic glutamate receptor 5b

Grm5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grm5	P31424	Tamalin	Rattus norvegicus	Q8R4T5	SPR	17396155
Intra	Grm5	P31424	Tamalin	Rattus norvegicus	Q8R4T5	Anti Tag CoIP	17396155
Intra	Grm5	P31424	Ppp1cc	Rattus norvegicus	P63088	CoIP	14519764
Intra	Grm5	P31424	Ppp1cc	Rattus norvegicus	P63088	Pull Down	14519764
Intra	Grm5	P31424	Ppp1cc	Rattus norvegicus	P63088	Y2H	14519764

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05831	GRM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05832	Grm5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05833	Grm5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm5	NCBI	NCBI:2915

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