Grm5 - glutamate metabotropic receptor 5 Gene

Rattus norvegicus

Also known as mGluR5; mGlur5

Gene ID: 24418 | Gene type: protein coding

About Grm5

Primary_assembly 1: 141,312,368-141,882,274 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 270 orthologues, 7 paralogues and is associated with 11 phenotypes. Restricted expression toward (RPKM 246.3).

Summary

Enables A2A Adenosine Receptor binding activity; glutamate receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and trans-synaptic signaling. Located in astrocyte projection; dendrite; and postsynaptic density membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Grm5 Products(1)

mRNA	Protein	Name
NM_017012.2	NP_058708.1	metabotropic glutamate receptor 5 precursor

Grm5 Protein Structure

PBP1_mGluR_groupI

NCD3G

7tmC_mGluR5

Herpes_BLLF1

GluR_Homer-bdg

0
200
400
600
800
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1203 a.a.

Protein Preferred Names

Protein Names

metabotropic glutamate receptor 5

glutamate receptor, metabotropic 5	metabotropic glutamate receptor (mGluR5)
metabotropic glutamate receptor 5b

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05831	GRM5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05832	Grm5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05833	Grm5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm5	NCBI	NCBI:2915

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