Nrp1 - neuropilin 1 Gene

Rattus norvegicus

Also known as Nrp

Gene ID: 246331 | Gene type: protein coding

About Nrp1

Summary

Enables semaphorin receptor activity. Involved in negative regulation of axon extension involved in axon guidance and response to wounding. Located in cell surface; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nrp1 Products(1)

mRNA	Protein	Name
NM_145098.2	NP_659566.1	neuropilin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9288754	RGD
enables semaphorin receptor activity	IMP IMP: Inferred from mutant phenotype	9288754	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	9288754	RGD
involved in positive regulation of platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26410366	RGD
involved in positive regulation of smooth muscle cell chemotaxis	IMP IMP: Inferred from mutant phenotype	26410366	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	26410366	RGD
involved in wound healing	IMP IMP: Inferred from mutant phenotype	26410366	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	9288754	RGD
located in cell surface	IDA IDA: Inferred from direct assay	9288754	RGD
located in growth cone	IDA IDA: Inferred from direct assay	9288754	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9288754	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuropilin-1

vascular endothelial cell growth factor 165 receptor

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P3448	Certepetide	Activator	99.40%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99386	Vesencumab	Inhibitor	≥99.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10799	EG00229 trifluoroacetate	Antagonist	98.18%	Unkown
HY-112151A	EG01377 dihydrochloride	Inhibitor	98.98%	Unkown
HY-P1663A	ATWLPPR Peptide TFA	Inhibitor	99.81%	Unkown
HY-133034	NRP1 antagonist 1	Antagonist	99.80%	Unkown
HY-147762	NRP1 antagonist 2	Antagonist	99.05%	Unkown
HY-RS09579	NRP1 Human Pre-designed siRNA Set A		/	Unkown
HY-112151	EG01377	Inhibitor	/	Unkown
HY-163062	Tubulin/NRP1-IN-1		/	Unkown
HY-P10097	Flt2₋11	Inhibitor	/	Unkown
HY-P10787	tLyP-1 peptide	Inhibitor	/	Unkown
HY-P10788	CK3 peptide	Inhibitor	/	Unkown
HY-128446	CAY10781	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrp1	NCBI	NCBI:8829
Macaca fascicularis	Nrp1	NCBI	NCBI:102145235
Mus musculus	Nrp1	NCBI	NCBI:18186

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