1. Gene
  2. NRP1 - neuropilin 1 Gene

NRP1 - neuropilin 1 Gene

Homo sapiens

Also known as NP1; NRP; BDCA4; CD304; VEGF165R

Gene ID: 8829 | Gene type: protein coding

About NRP1

Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:33,177,493-33,334,667 (from NCBI)

This gene has 14 transcripts (splice variants), 260 orthologues and 35 paralogues. Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues.

Summary

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

NRP1 Products(6)

mRNA Protein Name
NM_001024628.3 NP_001019799.2 neuropilin-1 isoform b precursor
NM_001024629.3 NP_001019800.2 neuropilin-1 isoform c precursor
NM_001244972.2 NP_001231901.2 neuropilin-1 isoform d precursor
NM_001244973.2 NP_001231902.2 neuropilin-1 isoform e precursor
NM_001330068.2 NP_001316997.2 neuropilin-1 isoform f precursor
NM_003873.7 NP_003864.5 neuropilin-1 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
26051942 GOA
enables growth factor binding IPI
IPI: Inferred from physical interaction
9529250 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16763549 GOA
enables vascular endothelial growth factor binding IPI
IPI: Inferred from physical interaction
24401374 GOA
Biological Process GO Annotation Evidence Reference Source
involved in VEGF-activated neuropilin signaling pathway IMP
IMP: Inferred from mutant phenotype
24863063 GOA
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
23639442 GOA
involved in cellular response to hepatocyte growth factor stimulus IMP
IMP: Inferred from mutant phenotype
21245381 GOA
involved in endothelial cell chemotaxis IMP
IMP: Inferred from mutant phenotype
21245381 GOA
involved in hepatocyte growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21245381 GOA
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24863063 GOA
involved in neuropilin signaling pathway IMP
IMP: Inferred from mutant phenotype
24863063 GOA
involved in platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21245381 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
24863063 GOA
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
26051942 GOA
involved in positive regulation of focal adhesion assembly IDA
IDA: Inferred from direct assay
24863063 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
26051942 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
24863063 GOA
involved in regulation of Cdc42 protein signal transduction IMP
IMP: Inferred from mutant phenotype
26051942 GOA
acts upstream of substrate-dependent cell migration, cell extension IMP
IMP: Inferred from mutant phenotype
24863063 GOA
involved in symbiont entry into host cell IDA
IDA: Inferred from direct assay
33000221 GOA
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21245381 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
21245381 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
24863063 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21245381 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRP1 Protein Structure

CUB

CUB: CUB domain (27 - 138)

CUB

CUB: CUB domain (147 - 262)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (290 - 421)

F5_F8_type_C

F5_F8_type_C: F5/8 type C domain (446 - 580)

MAM

MAM: MAM domain, meprin/A5/mu (650 - 810)

DUF3481

DUF3481: C-terminal domain of neuropilin glycoprotein (843 - 920)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 923 a.a.
Protein Preferred Names Protein Names

neuropilin-1

transmembrane receptor

NRP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NRP1 O14786 VEGFA Homo sapiens P15692
ELISA
17222790
Intra
NRP1 O14786 VEGFA Homo sapiens P15692
Anti Tag CoIP
16763549
Intra
NRP1 O14786 ITGA5 Homo sapiens P08648
Anti Bait CoIP
19175293
Cross
NRP1 O14786 S SARS-CoV-2 P0DTC2
Anti Tag CoIP
33082294
Cross
NRP1 O14786 S SARS-CoV-2 P0DTC2
ITC
33082294
Cross
NRP1 O14786 S SARS-CoV-2 P0DTC2
X-Ray Diffraction
33082294
Intra
NRP1 O14786 FLNA Homo sapiens P21333
ITC
24021649
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70147 Neuropilin-1 Protein, Human (HEK293, His) O14786-2 (F22-K644) ≥95%
HY-P72403 Neuropilin-1 Protein, Human (Biotinylated, HEK293, Avi-His) AAH07533.1 (F22-K644) ≥95%
HY-P73309 Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) O14786-2 (F22-K644, V179A) ≥95%
HY-P73310 Neuropilin-1 Protein, Human (V179A, HEK293, Fc) O14786-2 (F22-K644, V179A) ≥95%
HY-P78779 Neuropilin-1 Protein, Human (HEK293, Fc) AAH07533 (F22-K644) ≥95%

Related Diseases

Diseases Alias
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

Casil

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

Familial Vascular Leukoencephalopathy

CADASIL1

Cadasil 1

Hereditary Multi-Infarct Dementia

Cadasil Syndrome

Dementia, Hereditary Multiinfarct Type

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1

Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy

Dementia, Hereditary Multi-Infarct Type

Hereditary Dementia, Multi-Infarct Type

Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant

Dementia Hereditary Multiinfarct Type

Dementia Hereditary Multi-Infarct Type

Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy

Neuroma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Brain Edema

Cerebral Edema

Intracranial Swelling

Wet Brain

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome

Long Covid

Post-Acute Sequelae Of Sars-Cov-2 Infection

Chronic Covid-19

Pasc

Post-Covid Syndrome

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Angiomatous Meningioma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Charcot-Marie-Tooth Disease, Axonal, Type 2d

Charcot-Marie-Tooth Disease Type 2d

CMT2D

Charcot-Marie-Tooth Disease, Type 2d

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2d

Charcot-Marie-Tooth Disease Neuronal Type 2d

Charcot-Marie-Tooth Neuropathy Type 2d

Charcot-Marie-Tooth Disease, Neuronal, Type 2d

Charcot-Marie-Tooth Neuropathy, Type 2d

Charcot-Marie-Tooth Disease 2d

Charcot-Marie-Tooth Disease Axonal Type 2d

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 5

MVCD5

Retinopathy, Diabetic

Diabetic Nephropathy

Retinopathy, Diabetic, Susceptibility To

Retinal Abnormality - Diabetes-Related

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity

Retrolental Fibroplasia

EVR1

Criswick-Schepens Syndrome

Rop

Exudative Vitreoretinopathy, Familial, Autosomal Dominant

Fevr, Autosomal Dominant

Premature Retinopathy

Vitreoretinopathy, Exudative 1

Autosomal Dominant Familial Exudative Vitreoretinopathy

Fevr

Vitreoretinopathy, Exudative, Type 1

Retinopathy Of Prematurity Nos

Rlf- [Retrolental Fibroplasia]

Rop - [Retinopathy Of Prematurity]

Terry Syndrome

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus NRP1 VGNC VGNC:32266
Macaca mulatta NRP1 VGNC VGNC:75532
Felis catus NRP1 VGNC VGNC:68569
Mus musculus NRP1 MGD MGI:106206
Rattus norvegicus NRP1 RGD RGD:621588
Canis familiaris NRP1 VGNC VGNC:43974
Macaca fascicularis NRP1 NCBI NCBI:102145235
Others NRP1 NCBI