PPP2CA - Ppp2ca protein phosphatase 2 catalytic subunit alpha Gene

Rattus norvegicus

Also known as Pp2a1

Gene ID: 24672 | Gene type: protein coding

About PPP2CA

Summary

Enables several functions, including beta-2 Adrenergic Receptor binding activity; Enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of cellular protein metabolic process. Acts upstream of or within regulation of protein autophosphorylation; regulation of protein catabolic process; and regulation of signaling receptor activity. Located in cytosol; postsynaptic density; and terminal bouton. Part of protein Phosphatase type 2A complex. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein Phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

PPP2CA Products(1)

mRNA	Protein	Name
NM_017039.2	NP_058735.1	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-2 adrenergic receptor binding	IPI IPI: Inferred from physical interaction	20395454	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	18031790	RGD
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	19029245	RGD
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	15728831	RGD
enables protein antigen binding	IPI IPI: Inferred from physical interaction	8065321	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10984483	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	11884620	RGD
enables protein kinase B binding	IPI IPI: Inferred from physical interaction	11884620	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	18832448	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16899564	RGD
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	11884620	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	11032905	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	17897622	RGD
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	16519540	RGD
enables protein serine/threonine phosphatase activity	IMP IMP: Inferred from mutant phenotype	10640627	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11032905	RGD
enables tau protein binding	IPI IPI: Inferred from physical interaction	11032905	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	10984483	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac ventricle development	IEP IEP: Inferred from expression pattern	10861850	RGD
involved in cellular response to calcium ion	IEP IEP: Inferred from expression pattern	18322138	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	14567976	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	20224005	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	18372231	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	22509362	RGD
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24265448	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	11884620	RGD
involved in cellular response to steroid hormone stimulus	IEP IEP: Inferred from expression pattern	18079279	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	9432115	RGD
involved in negative regulation of calcium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15728831	RGD
involved in negative regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	18322138	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18832448	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18322138	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18322138	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18322138	RGD
involved in positive regulation of dephosphorylation	IMP IMP: Inferred from mutant phenotype	16884689	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	16519540	RGD
acts upstream of or within regulation of protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	19029245	RGD
acts upstream of or within regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	19029245	RGD
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19029245	RGD
acts upstream of or within regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	19029245	RGD
involved in response to lead ion	IDA IDA: Inferred from direct assay	22387731	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein phosphatase type 2A complex	IMP IMP: Inferred from mutant phenotype	19029245	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15728831	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

PP2A-alpha	protein phosphatase 2, catalytic subunit, alpha isozyme
protein phosphatase-2A-alpha

PPP2CA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ppp2ca	P63331	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	23892082
Intra	Ppp2ca	P63331	Dpysl2	Rattus norvegicus	P47942	Anti Bait CoIP	20220019

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11007	PPP2CA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PPP2CA	NCBI	NCBI:5515

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