TIPRL - TOR signaling pathway regulator Gene

Homo sapiens

Also known as TIP; TIP41; TIPRL1

Gene ID: 261726 | Gene type: protein coding

About TIPRL

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,178,962-168,202,109 (from NCBI)

This gene has 2 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues.

Summary

TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

TIPRL Products(2)

mRNA	Protein	Name
NM_001031800.3	NP_001026970.1	TIP41-like protein isoform 2
NM_152902.5	NP_690866.1	TIP41-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16085932	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17384681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIPRL Protein Structure

TIP41

0
100
200
272 a.a.

Protein Preferred Names

Protein Names

TIP41-like protein

TIP41, TOR signaling pathway regulator-like

TIPRL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TIPRL	O75663	PPP2CB	Homo sapiens	P62714	Anti Tag CoIP	16085932
Intra	TIPRL	O75663	PPP4C	Homo sapiens	P60510	Anti Bait CoIP	18614045
Intra	TIPRL	O75663	PPP4C	Homo sapiens	P60510	TAP	16085932
Intra	TIPRL	O75663	IGBP1	Homo sapiens	P78318	Anti Bait CoIP	23892082
Intra	TIPRL	O75663	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	17384681
Intra	TIPRL	O75663	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	17384681
Intra	TIPRL	O75663	PPP2CA	Homo sapiens	P67775	Anti Bait CoIP	23892082
Cross	TIPRL	O75663	Ppp2ca	Rattus norvegicus	P63331	Anti Tag CoIP	23892082

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14550	TIPRL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TIPRL	MGD	MGI:1915087
Macaca mulatta	TIPRL	VGNC	VGNC:79838
Canis familiaris	TIPRL	VGNC	VGNC:47383
Rattus norvegicus	TIPRL	RGD	RGD:1310442
Felis catus	TIPRL	VGNC	VGNC:107949
Bos taurus	TIPRL	VGNC	VGNC:35878

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