RICTOR - RPTOR independent companion of MTOR complex 2 Gene

Homo sapiens

Also known as PIA; AVO3; hAVO3

Gene ID: 253260 | Gene type: protein coding

About RICTOR

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:38,937,920-39,074,399 (from NCBI)

This gene has 10 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in bone marrow (RPKM 9.8), testis (RPKM 7.0) and 25 other tissues.

Summary

RICTOR and mTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

RICTOR Products(3)

mRNA	Protein	Name
NM_001285439.2	NP_001272368.1	rapamycin-insensitive companion of mTOR isoform 2
NM_001285440.2	NP_001272369.1	rapamycin-insensitive companion of mTOR isoform 3
NM_152756.5	NP_689969.2	rapamycin-insensitive companion of mTOR isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	29567957	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15467718	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21177249	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	16221682	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TORC2 signaling	IDA IDA: Inferred from direct assay	16221682	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15268862	GOA
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	21177249	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	15467718	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15467718	GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15718470	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TORC2 complex	IDA IDA: Inferred from direct assay	15268862	GOA
part of TORC2 complex	IPI IPI: Inferred from physical interaction	17461779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RICTOR Protein Structure

RICTOR_N

RICTOR_M

RasGEF_N_2

RICTOR_V

RICTOR_phospho

0
300
600
900
1200
1500
1708 a.a.

Protein Preferred Names

Protein Names

rapamycin-insensitive companion of mTOR

AVO3 homolog

RICTOR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RICTOR	Q6R327	PREX1	Homo sapiens	Q8TCU6	Anti Tag CoIP	17565979
Intra	RICTOR	Q6R327	PREX1	Homo sapiens	Q8TCU6	Anti Tag CoIP	21339740
Intra	RICTOR	Q6R327	YWHAE	Homo sapiens	P62258	CoIP	19935711
Intra	RICTOR	Q6R327	YWHAE	Homo sapiens	P62258	TAP	17461779
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	TAP	17461779
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Bait CoIP	18339839
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Bait CoIP	17461779
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Bait CoIP	18566587
Intra	RICTOR	Q6R327	MTOR	Homo sapiens	P42345	Anti Tag CoIP	17565979
Intra	RICTOR	Q6R327	SFN	Homo sapiens	P31947	TAP	15778465
Intra	RICTOR	Q6R327	ILK	Homo sapiens	Q13418	IF	18339839
Intra	RICTOR	Q6R327	ILK	Homo sapiens	Q13418	Anti Bait CoIP	18339839

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Tuberous Sclerosis

Tuberous Sclerosis Syndrome	Bourneville'S Disease
Epiloia	Cerebral Sclerosis
Tuberose Sclerosis	Tuberous Sclerosis 1
Bourneville Disease	Bourneville Phakomatosis
Pringle'S Disease

Subependymal Glioma

Mixed Subependymoma-Ependymoma	Subependymal Astrocytoma
Who Grade I Ependymal Tumor	Glioma, Subependymal

Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma

Subependymal Giant Cell Astrocytoma

Sega	Astrocytoma Subependymal Giant Cell
Subependymal Giant-Cell Astrocytoma

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Severe Myoclonic Epilepsy In Infancy
Smei	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Developmental And Epileptic Encephalopathy, 6	Dee6
Developmental And Epileptic Encephalopathy 6	Early Infantile Epileptic Encephalopathy 6
Myoclonic Epilepsy, Severe, Of Infancy	Sme
Severe Myoclonus Epilepsy Of Infancy	Borderline Smei
Smeb	Smeb-M
Smeb-O	Smeb-Sw
Smei-Borderland	Smei-Borderland More Than One Feature
Smei-Borderland-Myoclonic Seizures	Smei-Borderland-Spike Wave
Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures	ICEGTC
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Benign Ependymoma

Ependymoma	Epithelial Ependymoma
Who Grade Ii Ependymal Tumor	Myxopapillary Ependymoma

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Myopathy

Muscular Diseases

Myopathies

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122022	JR-AB2-011	Inhibitor	99.16%	Unkown
HY-RS11969	RICTOR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RICTOR	VGNC	VGNC:64626
Canis familiaris	RICTOR	VGNC	VGNC:45574
Mus musculus	RICTOR	MGD	MGI:1926007
Bos taurus	RICTOR	VGNC	VGNC:33963
Rattus norvegicus	RICTOR	RGD	RGD:1307224
Macaca mulatta	RICTOR	VGNC	VGNC:76853

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