PREX1 - phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 Gene

Homo sapiens

Also known as P-REX1

Gene ID: 57580 | Gene type: protein coding

About PREX1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:48,624,252-48,888,185 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 3 paralogues. Broad expression in spleen (RPKM 30.0), brain (RPKM 23.2) and 23 other tissues.

Summary

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

PREX1 Products(1)

mRNA	Protein	Name
NM_020820.4	NP_065871.3	phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid binding	IDA IDA: Inferred from direct assay	11955434	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17565979	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11955434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PREX1 Protein Structure

RhoGEF

DEP

0
300
600
900
1200
1500
1659 a.a.

Protein Preferred Names

Protein Names

phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

PIP3 dependent Rac exchange factor 1

PREX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PREX1	Q8TCU6	RICTOR	Homo sapiens	Q6R327	Anti Tag CoIP	21339740
Intra	PREX1	Q8TCU6	CDC42	Homo sapiens	P60953-2	X-Ray Diffraction	27150042
Intra	PREX1	Q8TCU6	CDC42	Homo sapiens	P60953-2	GMS	27150042
Cross	PREX1	Q8TCU6	Akt1	Mus musculus	P31750	Anti Tag CoIP	21339740
Intra	PREX1	Q8TCU6	MTOR	Homo sapiens	P42345	Pull Down	17565979
Intra	PREX1	Q8TCU6	RAC1	Homo sapiens	P63000-1	X-Ray Diffraction	27150042
Intra	PREX1	Q8TCU6	RAC1	Homo sapiens	P63000-1	GMS	27150042

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome	IMD73A
Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis	Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis
Rac 2 Deficiency

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104064	1A-116		99.79%	Unkown
HY-RS11085	PREX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PREX1	VGNC	VGNC:64351
Canis familiaris	PREX1	VGNC	VGNC:44962
Mus musculus	PREX1	MGD	MGI:3040696
Macaca mulatta	PREX1	VGNC	VGNC:76354
Bos taurus	PREX1	VGNC	VGNC:57017
Rattus norvegicus	PREX1	RGD	RGD:1306534

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