2. Gene
  3. ILK - integrin linked kinase Gene

ILK - integrin linked kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P59; ILK-1; ILK-2; p59ILK; HEL-S-28

Gene ID: 3611 | Gene type: protein coding

About ILK

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,603,774-6,610,870 (from NCBI)

This gene has 16 transcripts (splice variants), 254 orthologues and 23 paralogues. Ubiquitous expression in endometrium (RPKM 90.1), prostate (RPKM 80.8) and 25 other tissues.

Summary

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

ILK Products(5)

mRNA Protein Name
NM_001014794.3 NP_001014794.1 integrin-linked protein kinase isoform 1
NM_001014795.3 NP_001014795.1 integrin-linked protein kinase isoform 1
NM_001278441.2 NP_001265370.1 integrin-linked protein kinase isoform 2
NM_001278442.2 NP_001265371.1 integrin-linked protein kinase isoform 3
NM_004517.4 NP_004508.1 integrin-linked protein kinase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
20005845 GOA
enables integrin binding IDA
IDA: Inferred from direct assay
20005845 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
20005845 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11331308 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19118217 GOA
NOT enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
20005845 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
30254023 GOA
acts upstream of or within integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
9366252 GOA
involved in mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
18283114 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20018240 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21343177 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20018240 GOA
involved in positive regulation of signal transduction IMP
IMP: Inferred from mutant phenotype
10637513 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IGI
IGI: Inferred from genetic interaction
30254023 GOA
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19118217 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21343177 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
18283114 GOA
located in chromatin IDA
IDA: Inferred from direct assay
17420447 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17420447 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
30254023 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17420447 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILK Protein Structure

Ank

Ank: Ankyrin repeat (33 - 64)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (67 - 127)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (194 - 445)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 452 a.a.
Protein Preferred Names Protein Names

integrin-linked protein kinase

59 kDa serine/threonine-protein kinase

ILK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ILK Q13418 LIMS1 Homo sapiens P48059-3
Y2H Prey Pooling
32296183
Intra
ILK Q13418 LIMS1 Homo sapiens P48059-3
Y2H Array
32296183
Intra
ILK Q13418 RICTOR Homo sapiens Q6R327
Y2H
18339839
Intra
ILK Q13418 RICTOR Homo sapiens Q6R327
Anti Bait CoIP
18339839
Intra
ILK Q13418 RICTOR Homo sapiens Q6R327
Anti Tag CoIP
18339839
Intra
ILK Q13418 SLC4A1AP Homo sapiens Q9BWU0
Anti Tag CoIP
17553790
Intra
ILK Q13418 SLC4A1AP Homo sapiens Q9BWU0
Pull Down
17553790
Intra
ILK Q13418 ILKAP Homo sapiens Q9H0C8
Anti Bait CoIP
11331582
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Pull Down
19074270
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Tag CoIP
35271311
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
BiFC
23877428
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Y2H
11331308
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Pull Down
32707033
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Bait CoIP
17353931
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
X-Ray Diffraction
19074270
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Tag CoIP
18339839
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
TAP
23455922
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
GMS
19074270
Intra
ILK Q13418 LIMS1 Homo sapiens P48059
Anti Tag CoIP
25852190
Intra
ILK Q13418 SYNPO2 Homo sapiens Q9UMS6
Anti Bait CoIP
21643011
Intra
ILK Q13418 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
ILK Q13418 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
ILK Q13418 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
ILK Q13418 PARVG Homo sapiens Q9HBI0
Y2H Prey Pooling
25416956
Intra
ILK Q13418 PARVG Homo sapiens Q9HBI0
Validated Y2H
32296183
Intra
ILK Q13418 PARVG Homo sapiens Q9HBI0
Y2H Array
25416956
Intra
ILK Q13418 CASP9 Homo sapiens P55211
Anti Bait CoIP
16936772
Intra
ILK Q13418 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Validated Y2H
25416956
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Prey Pooling
32296183
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
TAP
23455922
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
26496610
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Validated Y2H
32296183
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Array
25416956
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
25852190
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
33961781
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H
11331308
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Array
32296183
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Pooling
16189514
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
BiFC
23877428
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Pull Down
17553790
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Pull Down
32707033
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Y2H Prey Pooling
25416956
Intra
ILK Q13418 PARVA Homo sapiens Q9NVD7
Anti Tag CoIP
35271311
Intra
ILK Q13418 CASP8 Homo sapiens Q14790
Anti Bait CoIP
16936772
Cross: Cross-species interaction Intra: Intraspecies interaction

ILK Antibodies

Cat. No. Product Name Application Reactivity
HY-P83366 Integrin Linked ILK Antibody (YA3111) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Renal Fibrosis
Hyperphosphatemia
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma

Anaplastic Thyroid Cancer

Thyroid Cancer, Anaplastic

Thyroid Carcinoma, Anaplastic

Thyroid Carcinoma Anaplastic
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18676 OSU-T315 99.88% Unkown
HY-113439 12-HETE Inhibitor 95.70% Unkown
HY-115677 ILK-IN-3 Inhibitor 99.62% Unkown
HY-18676B ILK-IN-2 99.41% Unkown
HY-113439S 12-HETE-d8 Inhibitor ≥98.0% Unkown
HY-RS06787 ILK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ILK VGNC VGNC:73738
Mus musculus ILK MGD MGI:1195267
Rattus norvegicus ILK RGD RGD:620063
Bos taurus ILK VGNC VGNC:30177
Canis familiaris ILK VGNC VGNC:42001
Felis catus ILK VGNC VGNC:67792
Others ILK NCBI