Aldh3a1 - aldehyde dehydrogenase 3 family, member A1 Gene

Rattus norvegicus

Also known as AHDC; Aldh; Ahd-c; Aldh3

Gene ID: 25375 | Gene type: protein coding

About Aldh3a1

Primary_assembly 10: 45,892,924-45,902,681 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 370 orthologues, 20 paralogues and is associated with 5 phenotypes. Biased expression in Lung (RPKM 46.8), Heart (RPKM 25.7) and 4 other tissues.

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh3a1 Products(1)

mRNA	Protein	Name
NM_031972.2	NP_114178.1	aldehyde dehydrogenase, dimeric NADP-preferring

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-chloroallyl aldehyde dehydrogenase activity	IDA IDA: Inferred from direct assay	2831537	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12604187	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	9013560	RGD
involved in response to glucocorticoid	IDA IDA: Inferred from direct assay	10101022	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	11306047	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	7751973	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	18203689	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	12604189	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	10323327	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10323328	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	11306046	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh3a1 Protein Structure

ALDH_F3AB

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

aldehyde dehydrogenase, dimeric NADP-preferring

Aldehyde dehydrogenase (Ahd-c)	HTC-ALDH
aldehyde dehydrogenase 3A1	aldehyde dehydrogenase class 3
aldehyde dehydrogenase family 3 member A1	aldehyde dehydrogenase family 3 subfamily A1
tumor-associated aldehyde dehydrogenase tumor ALDH

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0364A	Dyclonine hydrochloride	Inhibitor	99.86%	Unkown

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123962	G6PD activator AG1		99.54%	Unkown
HY-144670	ALDH3A1-IN-1	Inhibitor	≥95.0%	Unkown
HY-W017186	ALDH1A3-IN-3	Inhibitor	99.12%	Unkown
HY-144669	ALDH1A3-IN-2	Inhibitor	99.28%	Unkown
HY-146683	KS106		99.31%	Unkown
HY-146682	KS100		99.61%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	Unkown
HY-122577	EN40	Inhibitor	99.56%	Unkown
HY-134917	Aldi-2	Inhibitor	/	Unkown
HY-144671	ALDH3A1-IN-2	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-RS00571	ALDH3A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00572	Aldh3a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00573	Aldh3a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00575	ALDH3B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldh3a1	NCBI	NCBI:218

Name
Email *

	Sorry, but the email address you supplied was invalid.