2. Gene
  3. YTHDF3 - YTH N6-methyladenosine RNA binding protein 3 Gene

YTHDF3 - YTH N6-methyladenosine RNA binding protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DF3

Gene ID: 253943 | Gene type: protein coding

About YTHDF3

Cytogenetic location: 8q12.3 Genomic coordinates (GRCh38): 8:63,168,553-63,212,788 (from NCBI)

This gene has 16 transcripts (splice variants), 204 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 27.1), colon (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

YTHDF3 Products(7)

mRNA Protein Name
NM_001277813.2 NP_001264742.1 YTH domain-containing family protein 3 isoform b
NM_001277814.2 NP_001264743.1 YTH domain-containing family protein 3 isoform b
NM_001277815.2 NP_001264744.1 YTH domain-containing family protein 3 isoform c
NM_001277816.2 NP_001264745.1 YTH domain-containing family protein 3 isoform c
NM_001277817.2 NP_001264746.1 YTH domain-containing family protein 3 isoform c
NM_001277818.2 NP_001264747.1 YTH domain-containing family protein 3 isoform c
NM_152758.6 NP_689971.4 YTH domain-containing family protein 3 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
22575960 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
32194978 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
28106076 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA destabilization IDA
IDA: Inferred from direct assay
32492408 GOA
involved in mRNA destabilization IMP
IMP: Inferred from mutant phenotype
28106072 GOA
involved in organelle assembly IDA
IDA: Inferred from direct assay
31292544 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
28106072 GOA
NOT involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
32492408 GOA
involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
28106076 GOA
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
32492408 GOA
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
32194978 GOA
involved in regulation of trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
32194978 GOA
involved in stress granule assembly IDA
IDA: Inferred from direct assay
32451507 GOA
Cellular Component GO Annotation Evidence Reference Source
located in P-body IDA
IDA: Inferred from direct assay
32492408 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
32492408 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
32451507 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDF3 Protein Structure

YTH

YTH: YT521-B-like domain (415 - 550)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 584 a.a.
Protein Preferred Names Protein Names

YTH domain-containing family protein 3

YTH N(6)-methyladenosine RNA binding protein 3

YTHDF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
YTHDF3 Q7Z739 YTHDF1 Homo sapiens Q9BYJ9
Anti Tag CoIP
28514442
Intra
YTHDF3 Q7Z739 YTHDF1 Homo sapiens Q9BYJ9
Anti Tag CoIP
33961781
Intra
YTHDF3 Q7Z739 FAF1 Homo sapiens Q9UNN5
Validated Y2H
32296183
Intra
YTHDF3 Q7Z739 FAF1 Homo sapiens Q9UNN5
Y2H Array
32296183
Intra
YTHDF3 Q7Z739 FAF1 Homo sapiens Q9UNN5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15939 YTHDF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-168610 YTH-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus YTHDF3 VGNC VGNC:37043
Rattus norvegicus YTHDF3 RGD RGD:1305234
Macaca mulatta YTHDF3 VGNC VGNC:79614
Mus musculus YTHDF3 MGD MGI:1918850
Felis catus YTHDF3 VGNC VGNC:67153
Canis familiaris YTHDF3 VGNC VGNC:48507