2. Gene
  3. YTHDF1 - YTH N6-methyladenosine RNA binding protein 1 Gene

YTHDF1 - YTH N6-methyladenosine RNA binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DF1; C20orf21

Gene ID: 54915 | Gene type: protein coding

About YTHDF1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,195,429-63,216,131 (from NCBI)

This gene has 2 transcripts (splice variants), 262 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), bone marrow (RPKM 15.2) and 25 other tissues.

Summary

Enables N6-methyladenosine-containing RNA binding activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022]

YTHDF1 Products(1)

mRNA Protein Name
NM_017798.4 NP_060268.2 YTH domain-containing family protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: Inferred from direct assay
24284625 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28106072 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
26046440 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA destabilization IDA
IDA: Inferred from direct assay
32492408 GOA
involved in organelle assembly IDA
IDA: Inferred from direct assay
31292544 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
28106072 GOA
NOT involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
32492408 GOA
involved in positive regulation of translational initiation IDA
IDA: Inferred from direct assay
26046440 GOA
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
32492408 GOA
involved in stress granule assembly IDA
IDA: Inferred from direct assay
32451507 GOA
Cellular Component GO Annotation Evidence Reference Source
located in P-body IDA
IDA: Inferred from direct assay
32492408 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
32492408 GOA
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
32451507 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDF1 Protein Structure

YTH

YTH: YT521-B-like domain (390 - 524)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

YTH domain-containing family protein 1

DACA-1

YTHDF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra YTHDF1 Q9BYJ9 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 C6orf15 Homo sapiens Q6UXA7
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 C6orf15 Homo sapiens Q6UXA7
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Validated Y2H
32296183
Intra YTHDF1 Q9BYJ9 HSF4 Homo sapiens Q9ULV5-2
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 PRR32 Homo sapiens B1ATL7
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 PRR32 Homo sapiens B1ATL7
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 VPS37C Homo sapiens A5D8V6
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 YTHDF3 Homo sapiens Q7Z739
Anti Tag CoIP
33961781
Intra YTHDF1 Q9BYJ9 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra YTHDF1 Q9BYJ9 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Validated Y2H
32296183
Intra YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 HEY1 Homo sapiens Q9Y5J3
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 BATF2 Homo sapiens Q8N1L9
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 BATF2 Homo sapiens Q8N1L9
Y2H Array
32296183
Intra YTHDF1 Q9BYJ9 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra YTHDF1 Q9BYJ9 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ocular Melanoma

Intraocular Melanoma

Uveal Melanoma

Eye Melanoma

Melanoma Of Eye

Melanoma Of The Uvea

Malignant Melanoma Of Eye
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15937 YTHDF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-168610 YTH-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus YTHDF1 VGNC VGNC:67151
Bos taurus YTHDF1 VGNC VGNC:37041
Canis familiaris YTHDF1 VGNC VGNC:48505
Macaca mulatta YTHDF1 VGNC VGNC:78988
Rattus norvegicus YTHDF1 RGD RGD:1308932
Mus musculus YTHDF1 MGD MGI:1917431