ICAM1 - Icam1 intercellular adhesion molecule 1 Gene

Rattus norvegicus

Also known as CD54; ICAM

Gene ID: 25464 | Gene type: protein coding

About ICAM1

Summary

Enables Integrin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and gonad development. Located in cell surface; extracellular space; and plasma membrane. Used to study diabetic angiopathy; mesenteric vascular occlusion; nephritis; pre-eclampsia; and uveitis. Biomarker of several diseases, including cerebrovascular disease (multiple); colitis (multiple); kidney failure (multiple); lung disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; diabetic retinopathy; inflammatory bowel disease (multiple); and liver cirrhosis. Orthologous to human ICAM1 (intercellular adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

ICAM1 Products(1)

mRNA	Protein	Name
NM_012967.1	NP_037099.1	intercellular adhesion molecule 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IMP IMP: Inferred from mutant phenotype	16825578	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10556544	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	7641842	RGD
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	12097510	RGD
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8938183	RGD
involved in cellular response to alkaloid	IEP IEP: Inferred from expression pattern	20674665	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	10976991	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	20627932	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	20631551	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	20643106	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	7865494	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20674665	RGD
involved in cellular response to nutrient levels	IEP IEP: Inferred from expression pattern	20643106	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	15087287	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	7865494	RGD
involved in cellular senescence	IEP IEP: Inferred from expression pattern	20421514	RGD
involved in establishment of Sertoli cell barrier	IDA IDA: Inferred from direct assay	22976294	RGD
involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	10201790	RGD
involved in negative regulation of calcium ion transport	IDA IDA: Inferred from direct assay	15087287	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	20591976	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	17662049	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	9062344	RGD
involved in positive regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	17662049	RGD
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	10517906	RGD
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	9062344	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	17662049	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	12296653	RGD
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	15087287	RGD
involved in response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	IEP IEP: Inferred from expression pattern	20870297	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	20599905	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	21093552	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	20544302	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20726338	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	20591976	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19823174	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	18791499	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	20385203	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20871155	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20740350	RGD
involved in response to sulfur dioxide	IEP IEP: Inferred from expression pattern	20951496	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20871620	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8938183	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	18413153	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intercellular adhesion molecule 1

ICAM-1

Recombinant ICAM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73114	ICAM-1/CD54 Protein, Rat (HEK293, His)	Q00238 (Q28-T493)	≥95%
HY-P73909	ICAM-1/CD54 Protein, Rat (HEK293, Fc)	Q00238 (Q28-T493)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19344	Lifitegrast	Antagonist	99.29%	Unkown
HY-19344A	Lifitegrast sodium	Inhibitor	99.33%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145728	Alicaforsen	Inhibitor	/	Phase 3
HY-145728A	Alicaforsen sodium	Inhibitor	/	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99473	Bersanlimab	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100226	A-205804	Inhibitor	98.12%	Unkown
HY-33037	Phenazine-1-carboxylic acid	Inhibitor	99.88%	Unkown
HY-15701	Leukadherin-1	Agonist	≥98.0%	Unkown
HY-110117	BIRT 377	Inhibitor	98.07%	Unkown
HY-P1110	AF12198	Inhibitor	99.75%	Unkown
HY-N0602	Ginsenoside Rg2	Inhibitor	98.11%	Unkown
HY-107587	A-286982	Inhibitor	99.33%	Unkown
HY-U00003	ICAM-1-IN-1	Inhibitor	99.93%	Unkown
HY-W588250	Surfactin C1	Antagonist	99.36%	Unkown
HY-145728B	(R/S)-Alicaforsen	Inhibitor	97.08%	Unkown
HY-10596	BMS-688521	Inhibitor	98.62%	Unkown
HY-P2508	MUC1, mucin core		99.85%	Unkown
HY-110086	RWJ 50271	Inhibitor	99.25%	Unkown
HY-W013557	3-Hydroxyxanthone	Inhibitor	≥98.0%	Unkown
HY-13412	Cariporide (mesilate)	Modulator	/	Unkown
HY-101961	Tyrphostin AG 1288	Inhibitor	98.68%	Unkown
HY-143243	Antioxidant agent-5	Inhibitor	/	Unkown
HY-N0602R	Ginsenoside Rg2 (Standard)	Inhibitor	/	Unkown
HY-N11996	Aloenin aglycone		/	Unkown
HY-N4275	Oleaside A		/	Unkown
HY-RS06512	ICAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-122192	ICAM-1988		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99336	Enlimomab	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ICAM1	NCBI	NCBI:3383
Canis familiaris	ICAM1	NCBI	NCBI:403975
Macaca mulatta	ICAM1	NCBI	NCBI:712280

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