2. Apoptosis Metabolic Enzyme/Protease Anti-infection Cytoskeleton NF-κB
  3. TNF Receptor Endogenous Metabolite Bacterial Integrin NF-κB
  4. Maltotetraose

Maltotetraose  (Synonyms: Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose)

Cat. No.: HY-N2464 Purity: ≥98.0%
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Handling Instructions Technical Support

Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases.

For research use only. We do not sell to patients.

Maltotetraose Chemical Structure

Maltotetraose Chemical Structure

CAS No. : 34612-38-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Maltotetraose:

Maltotetraose Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Maltotetraose

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Maltotetraose can serve as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Maltotetraose has oral active, and reduces TNF-α-induced inflammatory responses by inhibiting NF-κB activity and decreasing ICAM-1 expression. Maltotetraose also inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Additionally, Maltotetraose derivatives can function as probes for detecting bacterial infections by targeting the maltodextrin transporter. With good long-term safety, Maltotetraose holds promise for research in atherosclerosis-related diseases[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Maltotetraose (20-40 μM, 30 min) suppresses NF-κB activation and ICAM-1 expression, potentially aiding in the early prevention of atherosclerosis[2].
Maltotetraose (20 μM, 30 min) inhibits PDGF-induced vascular smooth muscle cell migration, suggesting a potential role in atherosclerosis prevention[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Maltotetraose Related Antibodies

Western Blot Analysis[2]

Cell Line: MOVAS-1 mouse vascular smooth muscle cells
Concentration: 20-40 μM
Incubation Time: 30 min (Cells were pretreated with Maltotetraose (20-40 μM) for 30 minutes, followed by TNF-α (10 ng/mL) stimulation for 3-8 hours)
Result: Inhibited the phosphorylation of NF-κB-related protein.

RT-PCR[2]

Cell Line: MOVAS-1 mouse vascular smooth muscle cells
Concentration: 20-40 μM
Incubation Time: 30 min (Cells were pretreated with Maltotetraose (20-40 μM) for 30 minutes, followed by TNF-α (10 ng/mL) stimulation for 3-8 hours)
Result: Significantly decreased ICAM-1 mRNA levels.

Cell Migration Assay [2]

Cell Line: MOVAS-1 mouse vascular smooth muscle cells
Concentration: 20 μM
Incubation Time: 30 min (Cells were pretreated with Maltotetraose (20 μM) for 30 minutes, followed by PDGF (20 ng/mL) stimulation for 6-7 days)
Result: Significantly inhibited PDGF-induced vascular smooth muscle cell migration and new blood vessel formation in aortic ring explants.
In Vivo

Maltotetraose (10% in diet or 5,000 mg/kg via p.o., once daily for 90 days) dose not induce significant toxicity, suggesting good long-term safety[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[3]
Dosage: Dietary group: 10% (equivalent to 6,818 mg/kg/day in males, 7,464 mg/kg/day in females); Gavage group: 1,000, 3,000, or 5,000 mg/kg/day
Administration: Dietary intake or oral gavage (p.o.), Once daily for 90 consecutive days
Result: Sid not cause mortality or severe adverse effects in rats over 90 days.
Reduced food intake but no significant body weight differences (The 5,000 mg/kg/day gavage group).
Molecular Weight

666.58

Formula

C24H42O21
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O[C@H](O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O)[C@H](O)[C@H]1O)[C@@]1([H])O[C@H]2O[C@@H]([C@@H](O[C@@]3([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)[C@H](O)[C@H]2O)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (187.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5002 mL 7.5010 mL 15.0019 mL
5 mM 0.3000 mL 1.5002 mL 3.0004 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (150.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.59%

SDS (393 KB)

COA (313 KB) HNMR (467 KB) RP-HPLC (177 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5002 mL 7.5010 mL 15.0019 mL 37.5049 mL
5 mM 0.3000 mL 1.5002 mL 3.0004 mL 7.5010 mL
10 mM 0.1500 mL 0.7501 mL 1.5002 mL 3.7505 mL
15 mM 0.1000 mL 0.5001 mL 1.0001 mL 2.5003 mL
20 mM 0.0750 mL 0.3750 mL 0.7501 mL 1.8752 mL
25 mM 0.0600 mL 0.3000 mL 0.6001 mL 1.5002 mL
30 mM 0.0500 mL 0.2500 mL 0.5001 mL 1.2502 mL
40 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9376 mL
50 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7501 mL
60 mM 0.0250 mL 0.1250 mL 0.2500 mL 0.6251 mL
80 mM 0.0188 mL 0.0938 mL 0.1875 mL 0.4688 mL
100 mM 0.0150 mL 0.0750 mL 0.1500 mL 0.3750 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Maltotetraose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maltotetraose34612-38-9Amylotetraose Fujioligo 450 α-1,4-TetraglucoseFujioligo450Fujioligo 450Fujioligo-450TNF ReceptorEndogenous MetaboliteBacterialIntegrinNF-κBTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBMOVAS-1 mouse vascular smooth muscle cellsAtherosclerosisProbebacterial infectionsInhibitorinhibitorinhibit

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