2. Anti-infection
  3. Fungal
  4. Phenazine-1-carboxylic acid

Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation.

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Phenazine-1-carboxylic acid Chemical Structure

Phenazine-1-carboxylic acid Chemical Structure

CAS No. : 2538-68-3

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Based on 1 publication(s) in Google Scholar

Phenazine-1-carboxylic acid Related Antibodies

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Description

Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].

In Vitro

Phenazine-1-carboxylic acid (10-100 µM, 24 and 48 hours) can effectively inhibit the proliferation of DU145 cells in a time- and dose-dependent manner[2].
Phenazine-1-carboxylic acid (50 µM, 24 hours) can induce apoptosis in DU145 cells through ROS generation and mitochondrial apoptosis pathways[2].
Phenazine-1-carboxylic acid (50 µM, 36 hours) can upregulate IL-8 and ICAM-1 expression, inhibit RANTES and MCP-1 release, and has potential immunomodulatory activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phenazine-1-carboxylic acid Related Antibodies

Cell Viability Assay[2]

Cell Line: DU145 prostate cancer cells
Concentration: 10, 25, 50, 75, 100 µM
Incubation Time: 24 and 48 hours
Result: Inhibited DU145 cell proliferation in a time- and dose-dependent manner, with the highest inhibition at the maximum concentration.

Apoptosis Analysis[2]

Cell Line: DU145 prostate cancer cells
Concentration: 50 µM
Incubation Time: 24 hours
Result: Induced reactive oxygen species (ROS) generation in DU145 cells, causing mitochondrial membrane depolarization and apoptosis.
In Vivo

Phenazine-1-carboxylic acid (2 and 3 µg/mL, added through E3 medium, single dose) significantly prevented V. anguillarum infection in zebrafish embryos[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish embryos infected with Vibrio anguillarum[4]
Dosage: 2 µg/mL and 3 µg/mL
Administration: Added through zebrafish embryo E3 medium, single dose
Result: Effectively inhibited V. anguillarum infection in zebrafish embryos and increased embryo hatching rate.
Molecular Weight

224.21

Formula

C13H8N2O2
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(O)C1=C(N=C(C=CC=C2)C2=N3)C3=CC=C1
Structure Classification
Initial Source

Truncatella angustata
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (22.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4601 mL 22.3005 mL 44.6010 mL 111.5026 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL 22.3005 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL 11.1503 mL
15 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4335 mL
20 mM 0.2230 mL 1.1150 mL 2.2301 mL 5.5751 mL
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Phenazine-1-carboxylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenazine-1-carboxylic acid2538-68-3FungalDU145 prostate cancer cellsZebrafish embryosAnti-cancerInhibitorinhibitorinhibit

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