CALHM1 - calcium homeostasis modulator 1 Gene

Homo sapiens

Also known as FAM26C

Gene ID: 255022 | Gene type: protein coding

About CALHM1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,453,240-103,458,900 (from NCBI)

This gene has 1 transcript (splice variant), 217 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a Calcium Channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]

CALHM1 Products(1)

mRNA	Protein	Name
NM_001001412.4	NP_001001412.3	calcium homeostasis modulator protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-activated cation channel activity	IDA IDA: Inferred from direct assay	22711817	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18585350	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables voltage-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	22711817	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP export	IDA IDA: Inferred from direct assay	32832629	GOA
involved in monoatomic cation transport	IDA IDA: Inferred from direct assay	22711817	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	23300080	GOA
involved in regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	23300080	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22711817	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALHM1 Protein Structure

Ca_hom_mod

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

calcium homeostasis modulator protein 1

family with sequence similarity 26, member C

CALHM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CALHM1	Q8IU99	CALHM1	Homo sapiens	Q8IU99	Anti Tag CoIP	18585350
Intra	CALHM1	Q8IU99	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	CALHM1	Q8IU99	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053
Intra	CALHM1	Q8IU99	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	CALHM1	Q8IU99	CALHM1	Homo sapiens	Q8IU99	Comig Non-Denat Gel	18585350

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117073	ITH12575	Inhibitor	99.14%	Unkown
HY-RS01837	CALHM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CALHM1	VGNC	VGNC:26707
Felis catus	CALHM1	VGNC	VGNC:60323
Macaca mulatta	CALHM1	VGNC	VGNC:70615
Mus musculus	CALHM1	MGD	MGI:3643383
Canis familiaris	CALHM1	VGNC	VGNC:38667
Rattus norvegicus	CALHM1	RGD	RGD:1564891

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