GABPB1 - GA binding protein transcription factor subunit beta 1 Gene

Homo sapiens

Also known as E4TF1; GABPB; BABPB2; E4TF1B; GABPB2; NRF2B1; NRF2B2; GABPB-1; E4TF1-47; E4TF1-53

Gene ID: 2553 | Gene type: protein coding

About GABPB1

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:50,275,389-50,355,198 (from NCBI)

This gene has 11 transcripts (splice variants), 152 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 6.9), lymph node (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GABPB1 Products(7)

mRNA	Protein	Name
NM_001320910.2	NP_001307839.1	GA-binding protein subunit beta-1 isoform beta 1
NM_001320915.2	NP_001307844.1	GA-binding protein subunit beta-1 isoform 5
NM_002041.5	NP_002032.2	GA-binding protein subunit beta-1 isoform gamma 1
NM_005254.6	NP_005245.2	GA-binding protein subunit beta-1 isoform beta 1
NM_016654.5	NP_057738.1	GA-binding protein subunit beta-1 isoform beta 2
NM_016655.5	NP_057739.1	GA-binding protein subunit beta-1 isoform gamma 2
NM_181427.4	NP_852092.1	GA-binding protein subunit beta-1 isoform gamma 2

Protein Preferred Names

Protein Names

GA-binding protein subunit beta-1

GA binding protein transcription factor beta subunit 1

GABPB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GABPB1	Q06547	SNRPB2	Homo sapiens	P08579	Validated Y2H	25416956
Intra	GABPB1	Q06547	POGZ	Homo sapiens	Q7Z3K3	Y2H Prey Pooling	25416956
Intra	GABPB1	Q06547	POGZ	Homo sapiens	Q7Z3K3	Y2H Array	25416956
Intra	GABPB1	Q06547	IL16	Homo sapiens	Q14005-2	Y2H Prey Pooling	32296183
Intra	GABPB1	Q06547	IL16	Homo sapiens	Q14005-2	Y2H Array	32296183
Intra	GABPB1	Q06547	IL16	Homo sapiens	Q14005-2	Validated Y2H	32296183
Intra	GABPB1	Q06547	LMO4	Homo sapiens	P61968	Y2H Array	25416956
Intra	GABPB1	Q06547	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	GABPB1	Q06547	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	GABPB1	Q06547	TRAF2	Homo sapiens	Q12933	Y2H	21516116
Intra	GABPB1	Q06547	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	GABPB1	Q06547	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	GABPB1	Q06547	MED20	Homo sapiens	Q9H944	Y2H Array	32296183
Intra	GABPB1	Q06547	MED20	Homo sapiens	Q9H944	Validated Y2H	32296183
Intra	GABPB1	Q06547	MED20	Homo sapiens	Q9H944	Y2H Prey Pooling	32296183
Intra	GABPB1	Q06547	HCFC1	Homo sapiens	P51610	Pull Down	10675337
Intra	GABPB1	Q06547	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	25416956
Intra	GABPB1	Q06547	SNRPA	Homo sapiens	P09012	Validated Y2H	25416956
Intra	GABPB1	Q06547	TDRD7	Homo sapiens	Q8NHU6	Anti Tag CoIP	33961781
Intra	GABPB1	Q06547	TDRD7	Homo sapiens	Q8NHU6	Validated Y2H	25416956
Intra	GABPB1	Q06547	TDRD7	Homo sapiens	Q8NHU6	Y2H Array	25416956
Intra	GABPB1	Q06547	TDRD7	Homo sapiens	Q8NHU6	Y2H Pooling	16189514
Intra	GABPB1	Q06547	SNW1	Homo sapiens	Q13573	Y2H Prey Pooling	32296183
Intra	GABPB1	Q06547	SNW1	Homo sapiens	Q13573	Y2H Array	32296183
Intra	GABPB1	Q06547	SNW1	Homo sapiens	Q13573	Validated Y2H	32296183
Intra	GABPB1	Q06547	GABPA	Homo sapiens	Q06546	Y2H Array	32296183
Intra	GABPB1	Q06547	GABPA	Homo sapiens	Q06546	Y2H Prey Pooling	32296183
Intra	GABPB1	Q06547	GABPA	Homo sapiens	Q06546	Anti Tag CoIP	33961781
Intra	GABPB1	Q06547	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
Intra	GABPB1	Q06547	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	GABPB1	Q06547	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	GABPB1	Q06547	RBM11	Homo sapiens	P57052	Validated Y2H	25416956
Intra	GABPB1	Q06547	RBM11	Homo sapiens	P57052	Y2H Prey Pooling	25416956
Intra	GABPB1	Q06547	RBM11	Homo sapiens	P57052	Y2H Array	25416956
Intra	GABPB1	Q06547	MAGEB18	Homo sapiens	Q96M61	Y2H Pooling	19060904
Intra	GABPB1	Q06547	MAGEB18	Homo sapiens	Q96M61	Y2H Pooling	16189514
Intra	GABPB1	Q06547	MAGEB18	Homo sapiens	Q96M61	Y2H Array	19060904
Intra	GABPB1	Q06547	RSPH14	Homo sapiens	Q9UHP6	Y2H Prey Pooling	25416956
Intra	GABPB1	Q06547	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	25416956
Intra	GABPB1	Q06547	RSPH14	Homo sapiens	Q9UHP6	Y2H Array	25416956
Intra	GABPB1	Q06547	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
Intra	GABPB1	Q06547	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
Intra	GABPB1	Q06547	LMO1	Homo sapiens	P25800	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05207	GABPB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GABPB1	RGD	RGD:1560391
Bos taurus	GABPB1	VGNC	VGNC:106750
Felis catus	GABPB1	VGNC	VGNC:80968
Canis familiaris	GABPB1	VGNC	VGNC:41051
Mus musculus	GABPB1	MGD	MGI:95611
Macaca mulatta	GABPB1	VGNC	VGNC:72845

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