DYNLT2B - dynein light chain Tctex-type 2B Gene

Homo sapiens (human)

Also known as SRTD17; TCTEX1D2

Gene ID: 255758 | Gene type: protein coding

About DYNLT2B

Summary

Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

DYNLT2B Products(1)

mRNA	Protein	Name
NM_001351628.2	NP_001338557.1	dynein light chain Tctex-type protein 2B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dynein intermediate chain binding	IPI IPI: Inferred from physical interaction	25830415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	25830415	GOA
involved in intraciliary retrograde transport	IMP IMP: Inferred from mutant phenotype	29742051	GOA
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25205765	GOA
involved in regulation of intraciliary retrograde transport	IMP IMP: Inferred from mutant phenotype	26044572	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with axoneme	IDA IDA: Inferred from direct assay	25830415	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	25830415	GOA
colocalizes with ciliary base	IDA IDA: Inferred from direct assay	25830415	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25205765	GOA
colocalizes with interphase microtubule organizing center	IDA IDA: Inferred from direct assay	25830415	GOA
colocalizes with spindle pole	IDA IDA: Inferred from direct assay	25830415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dynein light chain Tctex-type protein 2B

Tctex1 domain containing 2

tctex1 domain-containing protein 2

DYNLT2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNLT2B	Q8WW35	GTF2F2	Homo sapiens	P13984	TAP	20195357
Intra	DYNLT2B	Q8WW35	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	DYNLT2B	Q8WW35	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	DYNLT2B	Q8WW35	DYNLT1	Homo sapiens	P63172	TAP	27173435
Intra	DYNLT2B	Q8WW35	DYNLT1	Homo sapiens	P63172	Anti Tag CoIP	33961781
Intra	DYNLT2B	Q8WW35	CDKN2D	Homo sapiens	P55273	Y2H Array	32296183
Intra	DYNLT2B	Q8WW35	CDKN2D	Homo sapiens	P55273	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

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