GTF2F2 - general transcription factor IIF subunit 2 Gene

Homo sapiens

Also known as BTF4; RAP30; TF2F2; TFIIF

Gene ID: 2963 | Gene type: protein coding

About GTF2F2

Cytogenetic location: 13q14.12-q14.13 Genomic coordinates (GRCh38): 13:45,120,510-45,284,893 (from NCBI)

This gene has 3 transcripts (splice variants) and 289 orthologues. Ubiquitous expression in skin (RPKM 5.5), adrenal (RPKM 5.1) and 25 other tissues.

Summary

Predicted to enable RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in microtubule Cytoskeleton and nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]

GTF2F2 Products(1)

mRNA	Protein	Name
NM_004128.3	NP_004119.1	general transcription factor IIF subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7854423	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15351637	GOA
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8662660	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	15351637	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	15351637	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9841876	GOA
part of transcription factor TFIIF complex	IPI IPI: Inferred from physical interaction	11183778	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2F2 Protein Structure

TFIIF_beta

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

general transcription factor IIF subunit 2

ATP-dependent helicase GTF2F2

GTF2F2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GTF2F2	P13984	DYNLT2B	Homo sapiens	Q8WW35	Display Tech	20195357
Intra	GTF2F2	P13984	RPL27A	Homo sapiens	P46776	Display Tech	20195357
Intra	GTF2F2	P13984	URI1	Homo sapiens	O94763	Display Tech	20195357
Intra	GTF2F2	P13984	URI1	Homo sapiens	O94763	Anti Tag CoIP	12737519
Intra	GTF2F2	P13984	URI1	Homo sapiens	O94763	Far-WB	12737519
Intra	GTF2F2	P13984	GTF2F1	Homo sapiens	P35269	Lumier	37398436
Intra	GTF2F2	P13984	GTF2F1	Homo sapiens	P35269	BRET	37398436
Intra	GTF2F2	P13984	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	GTF2F2	P13984	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	GTF2F2	P13984	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05897	GTF2F2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GTF2F2	VGNC	VGNC:97452
Rattus norvegicus	GTF2F2	RGD	RGD:620772
Mus musculus	GTF2F2	MGD	MGI:1915955
Macaca mulatta	GTF2F2	VGNC	VGNC:73310
Bos taurus	GTF2F2	VGNC	VGNC:53815

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