Ptpn11 - protein tyrosine phosphatase, non-receptor type 11 Gene

Rattus norvegicus

Also known as Shp2

Gene ID: 25622 | Gene type: protein coding

About Ptpn11

Summary

Enables several functions, including Insulin Receptor substrate binding activity; Phospholipase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; and positive regulation of focal adhesion assembly. Located in cytosol; mitochondrion; and plasma membrane raft. Part of protein-containing complex. Used to study glaucoma. Biomarker of glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine Phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn11 Products(2)

mRNA	Protein	Name
NM_001177593.1	NP_001171064.1	tyrosine-protein phosphatase non-receptor type 11 isoform 1
NM_013088.2	NP_037220.2	tyrosine-protein phosphatase non-receptor type 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	23328768	RGD
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	9388260	RGD
enables insulin receptor binding	IDA IDA: Inferred from direct assay	7711057	RGD
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	12891559	RGD
enables phospholipase binding	IDA IDA: Inferred from direct assay	16814162	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7545675	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10973965	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16690621	RGD
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	7512964	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	15115663	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	9139682	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19348936	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	9139682	RGD
involved in cellular response to mechanical stimulus	IPI IPI: Inferred from physical interaction	18757826	RGD
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	16905534	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	7711057	RGD
involved in smooth muscle cell proliferation	IEP IEP: Inferred from expression pattern	12117720	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane raft	IDA IDA: Inferred from direct assay	19348936	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	10973965	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 11

PTP-1D	SH-PTP2 protein tyrosine phosphatase, non-receptor type 11
SHP-2	encodes catalytic domain
protein tyrosine phosphatase SH-PTP2	protein-tyrosine phosphatase 1D
protein-tyrosine phosphatase SYP

Ptpn11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ptpn11	P41499	PDGFRB	Homo sapiens	P09619	Phosphatase Assay	7545675
Intra	Ptpn11	P41499	Sirpa	Rattus norvegicus	P97710	Far-WB	8810330
Intra	Ptpn11	P41499	Jak2	Rattus norvegicus	Q62689	Anti Bait CoIP	8912646

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101964	SPI-112	Inhibitor	97.06%	Unkown
HY-131132A	JAB-3068 hydrochloride	Inhibitor	98.88%	Unkown
HY-114460	SHP2-IN-1	Inhibitor	≥99.0%	Unkown
HY-131132	JAB-3068	Inhibitor	99.44%	Unkown
HY-120159	GS-493	Inhibitor	/	Unkown
HY-125259	SHP504	Inhibitor	/	Unkown
HY-RS11416	PTPN11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn11	NCBI	NCBI:5781
Mus musculus	Ptpn11	NCBI	NCBI:19247

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