NUDT14 - nudix hydrolase 14 Gene

Homo sapiens

Also known as UGPP; UGPPase

Gene ID: 256281 | Gene type: protein coding

About NUDT14

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,172,939-105,181,312 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 8.0), kidney (RPKM 7.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This Enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

NUDT14 Products(2)

mRNA	Protein	Name
NM_001318380.2	NP_001305309.1	uridine diphosphate glucose pyrophosphatase NUDT14 isoform 2
NM_177533.5	NP_803877.2	uridine diphosphate glucose pyrophosphatase NUDT14 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12620389	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT14 Protein Structure

NUDIX

0
100
200
222 a.a.

Protein Preferred Names

Protein Names

uridine diphosphate glucose pyrophosphatase NUDT14

UDP-sugar diphosphatase

NUDT14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUDT14	O95848	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	NUDT14	O95848	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	NUDT14	O95848	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	NUDT14	O95848	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	NUDT14	O95848	NUDT14	Homo sapiens	O95848	Y2H Array	31515488
Intra	NUDT14	O95848	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
Intra	NUDT14	O95848	NUDT14	Homo sapiens	O95848	Validated Y2H	32296183
Intra	NUDT14	O95848	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	NUDT14	O95848	NUDT14	Homo sapiens	O95848	Y2H Prey Pooling	32296183
Intra	NUDT14	O95848	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	NUDT14	O95848	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	NUDT14	O95848	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	NUDT14	O95848	NUDT14	Homo sapiens	O95848	Y2H Array	25416956
Intra	NUDT14	O95848	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
Intra	NUDT14	O95848	NUDT14	Homo sapiens	O95848	Y2H Array	32296183
Intra	NUDT14	O95848	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	NUDT14	O95848	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
Intra	NUDT14	O95848	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	NUDT14	O95848	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	NUDT14	O95848	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Array	25416956
Intra	NUDT14	O95848	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	NUDT14	O95848	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16965	TH287	Inhibitor	98.29%	Unkown
HY-158318	NUDT5/14 antagonist 1	Inhibitor	/	Unkown
HY-RS09664	NUDT14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-16965A	TH287 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NUDT14	VGNC	VGNC:80896
Canis familiaris	NUDT14	VGNC	VGNC:49752
Rattus norvegicus	NUDT14	RGD	RGD:1310583
Mus musculus	NUDT14	MGD	MGI:1913424
Bos taurus	NUDT14	VGNC	VGNC:32328

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