FRMD3 - FERM domain containing 3 Gene

Homo sapiens

Also known as 4.1O; P410; EPB41LO; EPB41L4O

Gene ID: 257019 | Gene type: protein coding

About FRMD3

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,242,992-83,585,794 (from NCBI)

This gene has 7 transcripts (splice variants), 228 orthologues and 10 paralogues. Broad expression in heart (RPKM 8.0), kidney (RPKM 5.0) and 20 other tissues.

Summary

The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

FRMD3 Products(6)

mRNA	Protein	Name
NM_001244959.2	NP_001231888.1	FERM domain-containing protein 3 isoform 2
NM_001244960.2	NP_001231889.1	FERM domain-containing protein 3 isoform 3
NM_001244961.2	NP_001231890.1	FERM domain-containing protein 3 isoform 4
NM_001244962.2	NP_001231891.1	FERM domain-containing protein 3 isoform 5
NM_001375487.1	NP_001362416.1	FERM domain-containing protein 3 isoform 6
NM_174938.6	NP_777598.3	FERM domain-containing protein 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRMD3 Protein Structure

FERM_N

FERM_M

FERM_C

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

FERM domain-containing protein 3

band 4.1-like protein 4

FRMD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FRMD3	A2A2Y4	TMEM218	Homo sapiens	A2RU14	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	CYB5B	Homo sapiens	O43169	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	TMEM201	Homo sapiens	Q5SNT2-2	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	SLC35A4	Homo sapiens	Q96G79	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	ZFPL1	Homo sapiens	O95159	Validated Y2H	32296183
Intra	FRMD3	A2A2Y4	SERP2	Homo sapiens	Q8N6R1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypertropia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05100	FRMD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FRMD3	VGNC	VGNC:40979
Rattus norvegicus	FRMD3	RGD	RGD:1304802
Mus musculus	FRMD3	MGD	MGI:2442466
Macaca mulatta	FRMD3	VGNC	VGNC:72769
Bos taurus	FRMD3	VGNC	VGNC:29113
Felis catus	FRMD3	VGNC	VGNC:62359

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