2. Gene
  3. PLPP4 - phospholipid phosphatase 4 Gene

PLPP4 - phospholipid phosphatase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DPPL2; PPAPDC1; PPAPDC1A

Gene ID: 196051 | Gene type: protein coding

About PLPP4

This gene has 3 transcripts (splice variants), 217 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

Enables diacylglycerol diphosphate Phosphatase activity; identical protein binding activity; and phosphatidate Phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

PLPP4 Products(5)

mRNA Protein Name
NM_001030059.3 NP_001025230.1 phospholipid phosphatase 4 isoform a
NM_001318166.2 NP_001305095.1 phospholipid phosphatase 4 isoform b
NM_001318167.2 NP_001305096.1 phospholipid phosphatase 4 isoform c
NM_001318168.2 NP_001305097.1 phospholipid phosphatase 4 isoform d
NM_001318169.2 NP_001305098.1 phospholipid phosphatase 4 isoform e
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables diacylglycerol diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
17590538 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables phosphatidate phosphatase activity EXP
EXP: Inferred from Experiment
17590538 GOA
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
17590538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in phospholipid dephosphorylation IDA
IDA: Inferred from direct assay
17590538 GOA
involved in regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
28851360 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP4 Protein Structure

PAP2

PAP2: PAP2 superfamily (84 - 226)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 4

diacylglycerol pyrophosphate like 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10737 PLPP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLPP4 MGD MGI:2685936
Bos taurus PLPP4 VGNC VGNC:33047
Canis familiaris PLPP4 VGNC VGNC:49792
Macaca mulatta PLPP4 VGNC VGNC:76097
Rattus norvegicus PLPP4 RGD RGD:1306289