PLPP4 - phospholipid phosphatase 4 Gene

Homo sapiens

Also known as DPPL2; PPAPDC1; PPAPDC1A

Gene ID: 196051 | Gene type: protein coding

About PLPP4

This gene has 3 transcripts (splice variants), 217 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

Enables diacylglycerol diphosphate Phosphatase activity; identical protein binding activity; and phosphatidate Phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

PLPP4 Products(5)

mRNA	Protein	Name
NM_001030059.3	NP_001025230.1	phospholipid phosphatase 4 isoform a
NM_001318166.2	NP_001305095.1	phospholipid phosphatase 4 isoform b
NM_001318167.2	NP_001305096.1	phospholipid phosphatase 4 isoform c
NM_001318168.2	NP_001305097.1	phospholipid phosphatase 4 isoform d
NM_001318169.2	NP_001305098.1	phospholipid phosphatase 4 isoform e

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol diphosphate phosphatase activity	IDA IDA: Inferred from direct assay	17590538	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables phosphatidate phosphatase activity	EXP EXP: Inferred from Experiment	17590538	GOA
enables phosphatidate phosphatase activity	IDA IDA: Inferred from direct assay	17590538	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phospholipid dephosphorylation	IDA IDA: Inferred from direct assay	17590538	GOA
involved in regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	28851360	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP4 Protein Structure

PAP2

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

phospholipid phosphatase 4

diacylglycerol pyrophosphate like 2

PLPP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLPP4	Q5VZY2	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	PLPP4	Homo sapiens	Q5VZY2	Y2H Array	25416956
Intra	PLPP4	Q5VZY2	PLPP4	Homo sapiens	Q5VZY2	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	PLPP4	Homo sapiens	Q5VZY2	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	GJA1	Homo sapiens	P17302	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	GJA1	Homo sapiens	P17302	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	CD74	Homo sapiens	P04233-2	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	CD74	Homo sapiens	P04233-2	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	PAGE1	Homo sapiens	O75459	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	PAGE1	Homo sapiens	O75459	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	EVI2A	Homo sapiens	P22794	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	EVI2A	Homo sapiens	P22794	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	LRRC59	Homo sapiens	Q96AG4	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	LRRC59	Homo sapiens	Q96AG4	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	LRRC59	Homo sapiens	Q96AG4	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	FRMD3	Homo sapiens	A2A2Y4	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	FRMD3	Homo sapiens	A2A2Y4	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	PLPP4	Q5VZY2	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	PLPP4	Q5VZY2	SYT2	Homo sapiens	Q8N9I0	Validated Y2H	32296183
Intra	PLPP4	Q5VZY2	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10737	PLPP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLPP4	MGD	MGI:2685936
Bos taurus	PLPP4	VGNC	VGNC:33047
Canis familiaris	PLPP4	VGNC	VGNC:49792
Macaca mulatta	PLPP4	VGNC	VGNC:76097
Rattus norvegicus	PLPP4	RGD	RGD:1306289

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