GCSAM - germinal center associated signaling and motility Gene

Homo sapiens

Also known as HGAL; GCAT2; GCET2

Gene ID: 257144 | Gene type: protein coding

About GCSAM

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,120,839-112,133,248 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 77 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 14.9), skin (RPKM 5.8) and 13 other tissues.

Summary

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GCSAM Products(3)

mRNA	Protein	Name
NM_001190259.2	NP_001177188.1	germinal center-associated signaling and motility protein isoform 3
NM_001190260.2	NP_001177189.1	germinal center-associated signaling and motility protein isoform 4
NM_152785.5	NP_689998.1	germinal center-associated signaling and motility protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IPI IPI: Inferred from physical interaction	17823310	GOA
enables myosin II binding	IPI IPI: Inferred from physical interaction	17823310	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20844236	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	23299888	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of lymphocyte migration	IMP IMP: Inferred from mutant phenotype	17823310	GOA
involved in regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23299888	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

germinal center-associated signaling and motility protein

germinal center B-cell-expressed transcript 2 protein

GCSAM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GCSAM	Q8N6F7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	GCSAM	Q8N6F7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	GCSAM	Q8N6F7	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	GCSAM	Q8N6F7	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	GCSAM	Q8N6F7	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GCSAM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81387	GCET2 Antibody (YA1132)	IHC-P	Human

Related Diseases

Diseases

Alias

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis	Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Alzheimer Disease 17

AD17	Alzheimer'S Disease 17
Alzheimer Disease 17, Late-Onset	Alzheimer Disease 17, Late Onset

Retroperitoneal Lymphoma

Nodal Marginal Zone Lymphoma

Mucosa-Associated Lymphoid Tissue Lymphoma

Monocytoid B-Cell Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05343	GCSAM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GCSAM	VGNC	VGNC:29293
Mus musculus	GCSAM	MGD	MGI:102969
Felis catus	GCSAM	VGNC	VGNC:102727
Rattus norvegicus	GCSAM	RGD	RGD:1591321
Macaca mulatta	GCSAM	VGNC	VGNC:72752
Canis familiaris	GCSAM	VGNC	VGNC:41152

Name
Email *

	Sorry, but the email address you supplied was invalid.