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  3. CNOT2 - CCR4-NOT transcription complex subunit 2 Gene

CNOT2 - CCR4-NOT transcription complex subunit 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NOT2; CDC36; NOT2H; HSPC131; IDNADFS

Gene ID: 4848 | Gene type: protein coding

About CNOT2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,243,018-70,354,993 (from NCBI)

This gene has 42 transcripts (splice variants), 266 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

CNOT2 Products(3)

mRNA Protein Name
NM_001199302.2 NP_001186231.1 CCR4-NOT transcription complex subunit 2 isoform a
NM_001199303.2 NP_001186232.1 CCR4-NOT transcription complex subunit 2 isoform a
NM_014515.7 NP_055330.1 CCR4-NOT transcription complex subunit 2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to poly(A)-specific ribonuclease activity IMP
IMP: Inferred from mutant phenotype
21299754 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10637334 GOA
enables transcription corepressor binding IDA
IDA: Inferred from direct assay
16712523 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16778766 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14707134 GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly IMP
IMP: Inferred from mutant phenotype
21299754 GOA
involved in regulation of stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
22367759 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21299754 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT2 Protein Structure

NOT2_3_5

NOT2_3_5: NOT2 / NOT3 / NOT5 family (395 - 522)

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  • 540 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 2

CC chemokine receptor 4-negative regulator of transcription 2

CNOT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CNOT2 Q9NZN8 ZFHX3 Homo sapiens Q15911-2
Y2H Array
32296183
Intra CNOT2 Q9NZN8 ZFHX3 Homo sapiens Q15911-2
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 GCSAM Homo sapiens Q8N6F7
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 GCSAM Homo sapiens Q8N6F7
Y2H Array
32296183
Intra CNOT2 Q9NZN8 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Intra CNOT2 Q9NZN8 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
26496610
Intra CNOT2 Q9NZN8 GPS1 Homo sapiens Q13098-7
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 GPS1 Homo sapiens Q13098-7
Y2H Array
32296183
Intra CNOT2 Q9NZN8 CIMIP1 Homo sapiens Q9H1P6
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 CIMIP1 Homo sapiens Q9H1P6
Y2H Array
32296183
Intra CNOT2 Q9NZN8 CNOT1 Homo sapiens A5YKK6
Y2H
10637334
Intra CNOT2 Q9NZN8 CNOT1 Homo sapiens A5YKK6
Anti Bait CoIP
16778766
Intra CNOT2 Q9NZN8 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
26496610
Intra CNOT2 Q9NZN8 GALNT10 Homo sapiens F2Z2M7
Y2H Array
32296183
Intra CNOT2 Q9NZN8 GALNT10 Homo sapiens F2Z2M7
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 MTFR1L Homo sapiens Q9H019
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 MTFR1L Homo sapiens Q9H019
Y2H Array
32296183
Intra CNOT2 Q9NZN8 TBX2 Homo sapiens Q13207
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 TBX2 Homo sapiens Q13207
Y2H Array
32296183
Intra CNOT2 Q9NZN8 PSMB4 Homo sapiens P28070
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 PSMB4 Homo sapiens P28070
Y2H Array
32296183
Intra CNOT2 Q9NZN8 ARMC5 Homo sapiens Q96C12
Y2H Array
32296183
Intra CNOT2 Q9NZN8 ARMC5 Homo sapiens Q96C12
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 TNRC6C Homo sapiens Q9HCJ0
Anti Tag CoIP
21981923
Intra CNOT2 Q9NZN8 BEX1 Homo sapiens Q9HBH7
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 BEX1 Homo sapiens Q9HBH7
Y2H Array
32296183
Intra CNOT2 Q9NZN8 CFAP68 Homo sapiens Q9H5F2
Y2H Prey Pooling
32296183
Intra CNOT2 Q9NZN8 CFAP68 Homo sapiens Q9H5F2
Y2H Array
32296183
Intra CNOT2 Q9NZN8 TOB1 Homo sapiens P50616
TAP
18377426
Intra CNOT2 Q9NZN8 CNOT8 Homo sapiens Q9UFF9
Anti Tag CoIP
26496610
Intra CNOT2 Q9NZN8 CNOT3 Homo sapiens O75175
Y2H Pooling
16189514
Intra CNOT2 Q9NZN8 CNOT3 Homo sapiens O75175
Y2H Array
20211142
Intra CNOT2 Q9NZN8 CNOT3 Homo sapiens O75175
Y2H Array
31515488
Intra CNOT2 Q9NZN8 CNOT3 Homo sapiens O75175
Anti Tag CoIP
26496610
Intra CNOT2 Q9NZN8 BCL6 Homo sapiens P41182
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder With Nasal Speech, Dysmorphic Facies, And Variable Skeletal Anomalies

IDNADFS
12q15q21.1 Microdeletion Syndrome

Del(12)(Q15)(Q21.1)

Deletion 12q15q21.1

Monosomy 12q15q21.1
Currarino Syndrome

Currarino Triad

Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation

CURRAS
Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease

SMA1

Spinal Muscular Atrophy 1

Sma I

Sma, Infantile Acute Form

Muscular Atrophy, Infantile

Spinal Muscular Atrophy-1

Hmn Proximal Type I

Infantile Muscular Atrophy

Proximal Spinal Muscular Atrophy Type 1

Sma Type 1

Sma Type I

Sma-I

Hereditary Motor Neuropathy Proximal Type I

Progressive Muscular Atrophy Of Infancy

Proximal Spinal Muscular Atrophy, Type 1

Werdnig Hoffmann Disease

Infantile Spinal Muscular Atrophy

Infantile-Onset Spinal Muscular Atrophy

Proximal Hereditary Motor Neuropathy Type I

Sma Infantile Acute Form

Spinal Muscular Atrophy Type I

Werdnig-Hoffman Disease

Atrophy, Muscular, Spinal, Type 1
Brachydactyly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02902 CNOT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CNOT2 VGNC VGNC:71387
Felis catus CNOT2 VGNC VGNC:68517
Mus musculus CNOT2 MGD MGI:1919318
Canis familiaris CNOT2 VGNC VGNC:39413
Bos taurus CNOT2 VGNC VGNC:27517
Rattus norvegicus CNOT2 RGD RGD:1311672