CNOT2 - CCR4-NOT transcription complex subunit 2 Gene

Homo sapiens

Also known as NOT2; CDC36; NOT2H; HSPC131; IDNADFS

Gene ID: 4848 | Gene type: protein coding

About CNOT2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,243,018-70,354,993 (from NCBI)

This gene has 42 transcripts (splice variants), 266 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

CNOT2 Products(3)

mRNA	Protein	Name
NM_001199302.2	NP_001186231.1	CCR4-NOT transcription complex subunit 2 isoform a
NM_001199303.2	NP_001186232.1	CCR4-NOT transcription complex subunit 2 isoform a
NM_014515.7	NP_055330.1	CCR4-NOT transcription complex subunit 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to poly(A)-specific ribonuclease activity	IMP IMP: Inferred from mutant phenotype	21299754	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10637334	GOA
enables transcription corepressor binding	IDA IDA: Inferred from direct assay	16712523	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16778766	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14707134	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IMP IMP: Inferred from mutant phenotype	21299754	GOA
involved in regulation of stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	22367759	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21299754	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT2 Protein Structure

NOT2_3_5

0
100
200
300
400
500
540 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 2

CC chemokine receptor 4-negative regulator of transcription 2

CNOT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT2	Q9NZN8	ZFHX3	Homo sapiens	Q15911-2	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	ZFHX3	Homo sapiens	Q15911-2	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	GCSAM	Homo sapiens	Q8N6F7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	GCSAM	Homo sapiens	Q8N6F7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT2	Q9NZN8	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	GPS1	Homo sapiens	Q13098-7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	GPS1	Homo sapiens	Q13098-7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CNOT1	Homo sapiens	A5YKK6	Y2H	10637334
Intra	CNOT2	Q9NZN8	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	16778766
Intra	CNOT2	Q9NZN8	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	GALNT10	Homo sapiens	F2Z2M7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	GALNT10	Homo sapiens	F2Z2M7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	MTFR1L	Homo sapiens	Q9H019	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	MTFR1L	Homo sapiens	Q9H019	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	TBX2	Homo sapiens	Q13207	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	TBX2	Homo sapiens	Q13207	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	ARMC5	Homo sapiens	Q96C12	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	ARMC5	Homo sapiens	Q96C12	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	CNOT2	Q9NZN8	BEX1	Homo sapiens	Q9HBH7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	BEX1	Homo sapiens	Q9HBH7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT2	Q9NZN8	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Y2H Pooling	16189514
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Y2H Array	20211142
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Y2H Array	31515488
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	BCL6	Homo sapiens	P41182	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Nasal Speech, Dysmorphic Facies, And Variable Skeletal Anomalies

IDNADFS

12q15q21.1 Microdeletion Syndrome

Del(12)(Q15)(Q21.1)	Deletion 12q15q21.1
Monosomy 12q15q21.1

Currarino Syndrome

Currarino Triad	Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation
CURRAS

Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease	SMA1
Spinal Muscular Atrophy 1	Sma I
Sma, Infantile Acute Form	Muscular Atrophy, Infantile
Spinal Muscular Atrophy-1	Hmn Proximal Type I
Infantile Muscular Atrophy	Proximal Spinal Muscular Atrophy Type 1
Sma Type 1	Sma Type I
Sma-I	Hereditary Motor Neuropathy Proximal Type I
Progressive Muscular Atrophy Of Infancy	Proximal Spinal Muscular Atrophy, Type 1
Werdnig Hoffmann Disease	Infantile Spinal Muscular Atrophy
Infantile-Onset Spinal Muscular Atrophy	Proximal Hereditary Motor Neuropathy Type I
Sma Infantile Acute Form	Spinal Muscular Atrophy Type I
Werdnig-Hoffman Disease	Atrophy, Muscular, Spinal, Type 1

Brachydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02902	CNOT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CNOT2	VGNC	VGNC:71387
Felis catus	CNOT2	VGNC	VGNC:68517
Mus musculus	CNOT2	MGD	MGI:1919318
Canis familiaris	CNOT2	VGNC	VGNC:39413
Bos taurus	CNOT2	VGNC	VGNC:27517
Rattus norvegicus	CNOT2	RGD	RGD:1311672

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